NR5A1

Gene Symbol	NR5A1
Entrez Gene	2516
Alt Symbol	AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3
Species	Human
Gene Type	protein-coding
Description	nuclear receptor subfamily 5, group A, member 1
Other Description	STF-1|adrenal 4 binding protein|adrenal 4-binding protein|fushi tarazu factor homolog 1|nuclear receptor AdBP4|steroid hormone receptor Ad4BP|steroidogenic factor 1|steroidogenic factor 1 nuclear receptor|steroidogenic factor-1
Swissprots	O15196 Q13285 Q5T6F5
Accessions	AAA75332 AAS48621 BAA13546 BAB18655 CCQ43292 EAW87591 Q13285 AB307718 BAH02309 AK090858 BC032501 AAH32501 EU446475 ABZ92004 HQ692856 ADZ17367 HQ709184 ADZ17391 JF432187 ADZ15404 U76388 AAB53105 XM_005251871 XP_005251928 XM_005251872 XP_005251929 XM_011518455 XP_011516757 XM_011518456 XP_011516758 NM_004959 NP_004950
Function	Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO- NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. {ECO:0000250, ECO:0000269|PubMed:17210646}.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:11479297}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Steroidogenic Factor 1 full length protein - ab114599 from Abcam Category Protein Source Wheat germ Species Human

Human Steroidogenic Factor 1 peptide - ab74765 from Abcam Category Peptide

Human Steroidogenic Factor 1 peptide - ab74766 from Abcam Category Peptide

NR5A1 / SF1 Antibody Blocking Peptide - LS-E29057 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NR5A1 / SF1 Antibody Blocking Peptide - LS-E29060 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NR5A1 / SF1 Antibody Blocking Peptide - LS-E29078 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NR5A1 / SF1 Antibody Blocking Peptide - LS-E7739 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NR5A1 / SF1 Antibody Blocking Peptide - LS-E11410 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NR5A1 / SF1 Antibody Blocking Peptide - LS-E28560 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NR5A1 / SF1 Antibody Blocking Peptide - LS-E16653 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NR5A1 / SF1 Antibody Blocking Peptide - LS-E16652 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NR5A1 / SF1 Antibody Blocking Peptide - LS-E13437 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NR5A1 / SF1 Antibody Blocking Peptide - LS-E13438 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SF-1/NR5A1/Steroidogenic Factor 1 Protein - H00002516-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

NR5A1-Antibody-N-term-Blocking-Peptide - BP5106a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NR5A1 Blocking Peptide - 33R-8589 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

NR5A1 Blocking Peptide - 33R-5322 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Steroidogenic factor 1 - H00002516-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Steroidogenic factor 1 - H00002516-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

NR5A1 fusion protein - Ag13252 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

NR5A1 fusion protein - ag13249 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human NR5A1 - NR5A1-31465TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human NR5A1, His-tagged - NR5A1-1361H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human NR5A1 - NR5A1-368H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human Steroidogenic factor 1(NR5A1) - CSB-YP623795HU CSB-EP623795HU CSB-BP623795HU CSB-MP623795HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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