NR5A1

Gene Symbol NR5A1
Entrez Gene 2516
Alt Symbol AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3
Species Human
Gene Type protein-coding
Description nuclear receptor subfamily 5, group A, member 1
Other Description STF-1|adrenal 4 binding protein|adrenal 4-binding protein|fushi tarazu factor homolog 1|nuclear receptor AdBP4|steroid hormone receptor Ad4BP|steroidogenic factor 1|steroidogenic factor 1 nuclear receptor|steroidogenic factor-1
Swissprots O15196 Q13285 Q5T6F5
Accessions AAA75332 AAS48621 BAA13546 BAB18655 CCQ43292 EAW87591 Q13285 AB307718 BAH02309 AK090858 BC032501 AAH32501 EU446475 ABZ92004 HQ692856 ADZ17367 HQ709184 ADZ17391 JF432187 ADZ15404 U76388 AAB53105 XM_005251871 XP_005251928 XM_005251872 XP_005251929 XM_011518455 XP_011516757 XM_011518456 XP_011516758 NM_004959 NP_004950
Function Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO- NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. {ECO:0000250, ECO:0000269|PubMed:17210646}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:11479297}.

STF-1 (D1Z2A) XP ® Rabbit mAb - 12800 from Cell Signaling Technology

Prices $277.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1Z2A
Western blot analysis of extracts from various cell lines using STF-1 (D1Z2A) XP ® Rabbit mAb (upper) and GAPDH (D16H11) XP ® Rabbit mAb #5174 (lower).

STF-1 Antibody - 8795 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

SF-1 (A-1) - sc-393592 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SF-1 (A-1): sc-393592. Western blot analysis of SF-1 expression in non-transfected 293T: sc-117752 (A), human SF-1 transfected 293T: sc-158953 (B) and Hep G2 (C) whole cell lysates.

SF-1 (G-12) - sc-398202 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SF-1 (G-12): sc-398202. Western blot analysis of SF-1 expression in non-transfected 293T: sc-117752 (A), human SF-1 transfected 293T: sc-158953 (B) and Hep G2 (C) whole cell lysates.

SF-1 (E-18) - sc-10976 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SF-1 (E-18): sc-10976. Western blot analysis of SF-1 expression in non-transfected: sc-117752 (A) and human SF-1 transfected: sc-158953 (B) 293T whole cell lysates.

SF-1 (H-60) - sc-28740 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SF-1 (H-60): sc-28740. Western blot analysis of SF-1 expression in THP-1 whole cell lysate.

SF-1 (P-17) - sc-10975 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SF-1 (P-17): sc-10975. Western blot analysis of SF-1 expression in non-transfected: sc-117752 (A) and human SF-1 transfected: sc-158953 (B) 293T whole cell lysates.

Anti-Steroidogenic Factor 1 antibody - ab79377 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Steroidogenic Factor 1 antibody (ab79377) at 1/500 dilutionLane 1 : Extracts from rat lungLane 2 : Extracts from rat lung with immunizing peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-Steroidogenic Factor 1 antibody [EPR11695(B)] - ab168380 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11695(B)
All lanes : Anti-Steroidogenic Factor 1 antibody [EPR11695(B)] (ab168380) at 1/1000 dilutionLane 1 : Jutkat cell lysateLane 2 : HepG2 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-NR5A1 / SF1 Antibody (aa70-100, APC) - LS-C216072 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR5A1 / SF1 Antibody (aa231-280) - LS-C145694 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
NR5A1 antibody LS-C145694 Western blot of HepG2 Cell lysate. Antibody concentration 1 ug/ml.

Anti-NR5A1 / SF1 Antibody (aa143-192) - LS-C111049 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
NR5A1 antibody Western blot of THP-1 cell lysate.

Anti-NR5A1 / SF1 Antibody (aa169-218) - LS-C118374 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from rat lung, using STF-1 (Ab-203) Antibody. The lane on the right is treated with the synthesized peptide.

Anti-NR5A1 / SF1 Antibody (aa70-100, Biotin) - LS-C216074 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR5A1 / SF1 Antibody (aa172-221) - LS-C29672 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
NR5A1 antibody LS-C29672 was used in IHC to stain formalin-fixed, paraffin-embedded human liver.

Anti-NR5A1 / SF1 Antibody (aa70-100, FITC) - LS-C216075 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR5A1 / SF1 Antibody (aa70-100, PE) - LS-C216078 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR5A1 / SF1 Antibody (aa70-100, Azide-free, HRP) - LS-C216077 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR5A1 / SF1 Antibody (aa133-402) - LS-C311764 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NR5A1 / SF1 Antibody (aa70-100) - LS-C329912 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR5A1 / SF1 Antibody (aa292-341) - LS-C170169 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-NR5A1 / SF1 Antibody (Internal) IHC-plus™ - LS-A5534 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NR5A1 antibody LS-A5534 IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-NR5A1 / SF1 Antibody (aa1-262, clone 1F2) - LS-C339851 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1F2
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NR5A1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NR5A1.

Anti-NR5A1 / SF1 Antibody (aa1-262, clone 1H2) - LS-C339877 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H2
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NR5A1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NR5A1.

Anti-NR5A1 / SF1 Antibody (Ligand-binding Domain) IHC-plus™ - LS-A5377 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NR5A1 antibody LS-A5377 IHC of human brain, caudate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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