| Gene Symbol |
KDM6B
|
| Entrez Gene |
23135
|
| Alt Symbol |
JMJD3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysine (K)-specific demethylase 6B
|
| Other Description |
jmjC domain-containing protein 3|jumonji domain containing 3, histone lysine demethylase|jumonji domain-containing protein 3|lysine demethylase 6B|lysine-specific demethylase 6B
|
| Swissprots |
O15054 Q96G33 C9IZ40
|
| Accessions |
EAW90127 EAW90128 O15054 AB002344 BAA21572 BC009994 AAH09994 BC035897 XM_005256549 XP_005256606 XM_005256550 XP_005256607 XM_005256551 XP_005256608 XM_005256552 XP_005256609 XM_005256554 XP_005256611 XM_006721483 XP_006721546 XM_006721484 XP_006721547 XM_011523750 XP_011522052 XM_011523751 XP_011522053 XM_011523752 XP_011522054 XM_011523753 XP_011522055 XM_011523754 XP_011522056 NM_001080424 NP_001073893
|
| Function |
Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. {ECO:0000269|PubMed:17825402, ECO:0000269|PubMed:17851529}.
|
| Subcellular Location |
Nucleus {ECO:0000305|PubMed:17825402}.
|