| Gene Symbol |
ANP32E
|
| Entrez Gene |
81611
|
| Alt Symbol |
LANP-L, LANPL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
|
| Other Description |
LANP-like protein|acidic leucine-rich nuclear phosphoprotein 32 family member E|leucine-rich acidic nuclear protein like
|
| Swissprots |
Q8WWW9 Q8N1S4 Q5TB20 B4E0I6 Q9BTT0 E9PEA6 Q5TB18
|
| Accessions |
CAI22806 CAI22807 CAI22808 CAI22809 EAW53575 EAW53576 EAW53577 EAW53578 EAW53579 Q9BTT0 AK025624 AK092672 BAC03942 AK095228 BAC04505 AK223469 BAD97189 AK303333 BAG64397 AK303392 BAG64448 AL832664 AL832674 AL833660 AM393076 CAL37954 AY057381 AAL25814 BC003380 AAH03380 BM974388 CB123292 DA379137 XM_005245513 XP_005245570 XM_005245514 XP_005245571 NM_001136478 NP_001129950 NM_001136479 NP_001129951 NM_001280559 NP_001267488 NM_001280560 NP_001267489 NM_030920 NP_112182
|
| Function |
Histone chaperone that specifically mediates the genome- wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis. {ECO:0000269|PubMed:24463511}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Expressed in peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver and kidney. {ECO:0000269|PubMed:12438741}.
|
![Western Blot: LANPL Overexpression Lysate (Adult Normal) [NBL1-07552] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LANPL.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5153_LANPL%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07552-img0002.jpg)