Gene Symbol | ANP32E |
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Entrez Gene | 81611 |
Alt Symbol | LANP-L, LANPL |
Species | Human |
Gene Type | protein-coding |
Description | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E |
Other Description | LANP-like protein|acidic leucine-rich nuclear phosphoprotein 32 family member E|leucine-rich acidic nuclear protein like |
Swissprots | Q8WWW9 Q8N1S4 Q5TB20 B4E0I6 Q9BTT0 E9PEA6 Q5TB18 |
Accessions | CAI22806 CAI22807 CAI22808 CAI22809 EAW53575 EAW53576 EAW53577 EAW53578 EAW53579 Q9BTT0 AK025624 AK092672 BAC03942 AK095228 BAC04505 AK223469 BAD97189 AK303333 BAG64397 AK303392 BAG64448 AL832664 AL832674 AL833660 AM393076 CAL37954 AY057381 AAL25814 BC003380 AAH03380 BM974388 CB123292 DA379137 XM_005245513 XP_005245570 XM_005245514 XP_005245571 NM_001136478 NP_001129950 NM_001136479 NP_001129951 NM_001280559 NP_001267488 NM_001280560 NP_001267489 NM_030920 NP_112182 |
Function | Histone chaperone that specifically mediates the genome- wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis. {ECO:0000269|PubMed:24463511}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
Tissue Specificity | Expressed in peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver and kidney. {ECO:0000269|PubMed:12438741}. |
LANPL CRISPR/Cas9 KO Plasmid (h) - sc-417348 from Santa Cruz Biotechnology
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LANPL HDR Plasmid (h) - sc-417348-HDR from Santa Cruz Biotechnology
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LANPL Double Nickase Plasmid (h) - sc-417348-NIC from Santa Cruz Biotechnology
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LANPL Double Nickase Plasmid (h2) - sc-417348-NIC-2 from Santa Cruz Biotechnology
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LANPL CRISPR Activation Plasmid (h) - sc-417348-ACT from Santa Cruz Biotechnology
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LANPL CRISPR Activation Plasmid (h2) - sc-417348-ACT-2 from Santa Cruz Biotechnology
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LANPL Lentiviral Activation Particles (h) - sc-417348-LAC from Santa Cruz Biotechnology
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LANPL Lentiviral Activation Particles (h2) - sc-417348-LAC-2 from Santa Cruz Biotechnology
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LANPL siRNA (h) - sc-75409 from Santa Cruz Biotechnology
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LANPL shRNA Plasmid (h) - sc-75409-SH from Santa Cruz Biotechnology
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LANPL shRNA (h) Lentiviral Particles - sc-75409-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU122141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3254 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3254 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11127 from Sigma-Aldrich
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ANP32E siRNA (Human) - CRJ3021 from Cohesion Biosciences
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ANP32E - MBS8230686 from MyBioSource
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shRNA set against Human ANP32E (NM_030920.3) - SHH237430 from Creative biogene
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ANP32E shRNA Plasmid (Human) - CHJ3021 from Cohesion Biosciences
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ANP32E miRNA 3'UTR clone - MiUTR4H-TG00375 from Creative biogene
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