MAML1

Gene Symbol MAML1
Entrez Gene 9794
Alt Symbol Mam-1, Mam1
Species Human
Gene Type protein-coding
Description mastermind-like 1 (Drosophila)
Other Description mastermind homolog|mastermind-like protein 1
Swissprots Q9NZ12 Q92585
Accessions EAW53801 Q92585 AA975821 AB209135 BAD92372 AF221759 AAF34658 AK295139 BAH11986 BC047937 D83785 BAA12114 NM_014757 NP_055572
Function Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}.
Subcellular Location Nucleus speckle {ECO:0000269|PubMed:11101851}. Note=Nuclear, in a punctate manner.
Tissue Specificity Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen. {ECO:0000269|PubMed:11101851}.
Top Pathways Notch signaling pathway

MAML1 (D3E9) Rabbit mAb - 11959 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3E9
Western blot analysis of extracts from various cell lines using MAML1 (D3E9) Rabbit mAb.

MAML1 (D3K7B) Rabbit mAb - 12166 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3K7B
Western blot analysis of extracts from various cell lines using MAML1 (D3K7B) Rabbit mAb.

MAML1 Antibody - 4608 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of total cell lysates from HeLa and 293 cells, using MAML1 antibody.

Mam1 (N-20) - sc-18506 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Mam1 (N-20): sc-18506. Western blot analysis of Mam1 expression in SK-N-MC nuclear extract.

Anti-MAML1 antibody - ab65090 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
MAML1 was immunoprecipitated using 0.5mg Hela whole cell extract, 5µg of Rabbit polyclonal to MAML1 and 50µl of protein G magnetic beads (+). No antibody was added to the control (-).The antibody was incubated under agitation with Protein G beads for 10min, Hela whole cell extract lysate diluted in RIPA buffer was added to each sample and incubated for a further 10min under agitation.Proteins were eluted by addition of 40µl SDS loading buffer and incubated for 10min at 70°C; 10µl of each sample was separated on a SDS PAGE gel, transferred to a nitrocellulose membrane, blocked with 5% BSA and probed with ab65090.Secondary: Mouse monoclonal [SB62a] Secondary Antibody to Rabbit IgG light chain (HRP) (ab99697).Band: 117kDa; MAML1

Anti-MAML1 antibody - ab70488 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human ovarian carcinoma tissue labelling MAML1 with ab70488 at 1/1000 (1µg/ml). Detection: DAB.

Anti-MAML1 antibody - ab17019 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-MAML1 antibody (ab17019) at 0.1 µg/ml + Tissue lysates prepared from Human skeletal muscles at 35 µg

Anti-MAML1 antibody - ab70486 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MAML1 antibody (ab70486) at 0.04 µg/mlLane 1 : Whole cell lysate from HeLa cells at 50 µgLane 2 : Whole cell lysate from HeLa cells at 15 µgLane 3 : Whole cell lysate from HeLa cells at 5 µgLane 4 : Whole cell lysate from 293T cells at 50 µgdeveloped using the ECL technique

Anti-MAML1 antibody - ab90654 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical detection of Human MAML1 in formalin-fixed parafin-embedded Human ovarian carcinoma tissue using ab90654 at a dilution of 1/250 (DAB staining).

Anti-MAML1 antibody - N-terminal - ab155786 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MAML1 antibody - N-terminal (ab155786) at 1/1000 dilution + Mouse heart whole cell lysate at 50 µg

Anti-MAML1 Antibody (aa661-676) - LS-C37281 from LifeSpan Bioscience

Prices $485.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-MAML1 Antibody (aa198-225, AP) - LS-C262472 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAML1 Antibody (aa198-225, APC) - LS-C262473 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAML1 Antibody (aa198-225, Biotin) - LS-C262474 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAML1 Antibody (aa198-225, FITC) - LS-C262475 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAML1 Antibody (aa198-225, Azide-free, HRP) - LS-C262476 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAML1 Antibody (aa198-225, PE) - LS-C262477 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAML1 Antibody (aa1-50) - LS-C287539 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MAML1 Antibody (aa205-234) - LS-C322807 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAML1 Antibody (aa198-225) - LS-C163979 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
MAML1 Antibody western blot of 293,NCI-H460 cell line lysates (35 ug/lane). The MAML1 antibody detected the MAML1 protein (arrow).

Anti-MAML1 Antibody (C-Terminus) - LS-C287542 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human MAML1 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-MAML1 used at a dilution of 1:200 (1 Detection: DAB.

Anti-MAML1 Antibody (aa75-125) - LS-C286670 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human MAML1 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-MAML1 used at a dilution of 1:250.

Anti-MAML1 Antibody (aa75-125) - LS-C287540 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human MAML1 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-MAML1 used at a dilution of 1:1000 (1 Detection: DAB.

Anti-MAML1 Antibody (aa2-15) IHC-plus™ - LS-B6462 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-MAML1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6462 concentration 2.5 ug/ml.

MAML1 Antibody - NBP1-33638 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MAML1 Antibody [NBP1-33638] - Sample (30 ug of whole cell lysate) A: HeLa B: HeLa nucleus 7.5% SDS PAGE; antibody diluted at 1:1000.
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