MAML1

Gene Symbol	MAML1
Entrez Gene	9794
Alt Symbol	Mam-1, Mam1
Species	Human
Gene Type	protein-coding
Description	mastermind-like 1 (Drosophila)
Other Description	mastermind homolog|mastermind-like protein 1
Swissprots	Q9NZ12 Q92585
Accessions	EAW53801 Q92585 AA975821 AB209135 BAD92372 AF221759 AAF34658 AK295139 BAH11986 BC047937 D83785 BAA12114 NM_014757 NP_055572
Function	Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}.
Subcellular Location	Nucleus speckle {ECO:0000269|PubMed:11101851}. Note=Nuclear, in a punctate manner.
Tissue Specificity	Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen. {ECO:0000269|PubMed:11101851}.
Top Pathways	Notch signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

SignalSilence ® MAML1 siRNA II - 12440 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® MAML1 siRNA I - 12386 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

Mam1 CRISPR/Cas9 KO Plasmid (h) - sc-404888 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Mam1 HDR Plasmid (h) - sc-404888-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Mam1 Double Nickase Plasmid (h) - sc-404888-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Mam1 Double Nickase Plasmid (h2) - sc-404888-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Mam1 CRISPR Activation Plasmid (h) - sc-404888-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Mam1 CRISPR Activation Plasmid (h2) - sc-404888-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Mam1 Lentiviral Activation Particles (h) - sc-404888-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Mam1 Lentiviral Activation Particles (h2) - sc-404888-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Mam1 siRNA (h) - sc-40731 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Mam1 shRNA Plasmid (h) - sc-40731-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Mam1 shRNA (h) Lentiviral Particles - sc-40731-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MAML1 RNAi - H00009794-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MAML1 RNAi - H00009794-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU043911 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN12956 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12956 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11362 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr11362

MAML1 siRNA (Human) - CRH6556 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human MAML1 (NM_014757.4) - SHH337187 from Creative biogene Category siRNA Species Reactivities Human

Human MAML1 siRNA - orb267058 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

MAML1 shRNA Plasmid (Human) - CHH6556 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

MAML1 miRNA 3'UTR clone - MiUTR4H-TG05313 from Creative biogene Species Reactivities Human

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