MAML1

Gene Symbol	MAML1
Entrez Gene	9794
Alt Symbol	Mam-1, Mam1
Species	Human
Gene Type	protein-coding
Description	mastermind-like 1 (Drosophila)
Other Description	mastermind homolog|mastermind-like protein 1
Swissprots	Q9NZ12 Q92585
Accessions	EAW53801 Q92585 AA975821 AB209135 BAD92372 AF221759 AAF34658 AK295139 BAH11986 BC047937 D83785 BAA12114 NM_014757 NP_055572
Function	Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}.
Subcellular Location	Nucleus speckle {ECO:0000269|PubMed:11101851}. Note=Nuclear, in a punctate manner.
Tissue Specificity	Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen. {ECO:0000269|PubMed:11101851}.
Top Pathways	Notch signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human MAML1 peptide - ab66491 from Abcam Category Peptide

Human MAML1 peptide - ab23302 from Abcam Category Peptide Species Human

Human MAML1 protein fragment - ab153018 from Abcam Category Protein Source Wheat germ Species Human

MAML1 Antibody Blocking Peptide - LS-E1068 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAML1 Antibody Blocking Peptide - LS-E25594 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAML1 Partial Recombinant Protein - H00009794-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

MAML1-Antibody-Center-Blocking-peptide - BP11558c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAML1 blocking peptide - GTX17019-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse

MAML1 Immunizing peptide - orb17103 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

MAML1 Peptide - AC21-0424-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Mastermind-Like Protein 1 - H00009794-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Mastermind-Like Protein 1 - H00009794-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MAML1 Peptide - 45-858P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

Recombinant Human Mastermind-like protein 1(MAML1) ,partial - CSB-YP838784HU CSB-EP838784HU CSB-BP838784HU CSB-MP838784HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Mastermind-Like Protein 1 - TP314790 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

MAML1/Mastermind, Peptide - MBS426189 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

MAML1 Recombinant Protein Antigen - NBP1-83025PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MAML1 Peptide, Human - M34GP09127H from Creative Peptides Category Peptide Source Synthetic. Species Human

MAML1 Recombinant Protein Antigen - NBP2-57191PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Mastermind-like protein 1 (MAML1), partial, Recombinant Protein - MBS1359550 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human MAML1 Protein, MYC/DDK-tagged - MAML1-330H from Creative Biomart Category Protein Source HEK293 Species Human

Search more