| Gene Symbol |
KIF2A
|
| Entrez Gene |
3796
|
| Alt Symbol |
CDCBM3, HK2, KIF2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kinesin heavy chain member 2A
|
| Other Description |
Kinesin, heavy chain, 2|kinesin-2|kinesin-like protein KIF2A
|
| Swissprots |
Q8N5Q7 D3DW97 Q7Z5I3 A5YM54 E9PB70 B4DY54 A5YM42 O00139
|
| Accessions |
EAW51387 EAW51388 EAW51389 EAW51390 O00139 AI652174 AK297347 BAG59797 AK302270 BAG63616 AK307880 AK315866 BAF98757 AY317140 AAP84320 AY429552 BC031828 AAH31828 BC047544 DB452624 DB456309 DQ891347 ABM82273 DQ894527 ABM85453 EF560716 ABQ59026 EF560728 ABQ59038 EU832810 ACE87821 GQ129246 ACT64380 Y08319 CAA69621 NM_001098511 NP_001091981 NM_001243952 NP_001230881 NM_001243953 NP_001230882 NM_004520 NP_004511
|
| Function |
Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. {ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:18411309}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Note=Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1.
|