| Gene Symbol |
NFX1
|
| Entrez Gene |
4799
|
| Alt Symbol |
NFX2, TEG-42, Tex42
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear transcription factor, X-box binding 1
|
| Other Description |
nuclear transcription factor, X box-binding protein 1|transcriptional repressor NF-X1
|
| Swissprots |
Q9BXI1 Q96EL5 Q12986 Q5VXW6 A8K6H8
|
| Accessions |
AAB94787 EAW58507 EAW58508 EAW58509 EAW58510 EAW58511 Q12986 AF332009 AAK16545 AI679589 AK055847 AK225750 AK291643 BAF84332 AL832342 AW674001 BC006447 AAH06447 BC012151 AAH12151 BP871782 BX647337 DA093124 DQ893676 ABM84602 DQ895843 ABM86769 U15306 AAA69517 XM_005251473 XP_005251530 XM_005251474 XP_005251531 XM_005251475 XP_005251532 NM_002504 NP_002495 NM_147133 NP_667344 NM_147134 NP_667345
|
| Function |
Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341, ECO:0000269|PubMed:17267499}.
|
| Subcellular Location |
Nucleus.
|
![Western Blot: NFX1 Overexpression Lysate (Adult Normal) [NBL1-13626] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NFX1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1482_NFX1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13626-img0002.jpg)