XAF1

Gene Symbol	XAF1
Entrez Gene	54739
Alt Symbol	BIRC4BP, HSXIAPAF1, XIAPAF1
Species	Human
Gene Type	protein-coding
Description	XIAP associated factor 1
Other Description	BIRC4 binding protein|BIRC4-binding protein|XIAP-associated factor 1
Swissprots	A2T932 A8K9Y3 Q99982 A8K2L1 A2T931 Q6MZE8 Q8N557 Q6GPH4 D3DTM6
Accessions	EAW90287 EAW90288 EAW90289 EAW90290 EAW90291 Q6GPH4 AK056908 BAG51823 AK091799 AK290276 BAF82965 AK292710 BAF85399 AK292848 BAF85537 BC032776 AAH32776 BC058017 BC073156 AAH73156 BM153640 BM459605 BM475564 BQ639060 BX648588 BX649188 CAE46206 EF028165 ABM74556 EF028166 ABM74557 X99699 CAA68030 XM_005256706 XP_005256763 XM_005256708 XP_005256765 XM_011523945 XP_011522247 XM_011523946 XP_011522248 XM_011523947 XP_011522249 XM_011523948 XP_011522250 XM_011523949 XP_011522251 XR_934053 XR_934054 XR_934055 XR_934057 NM_017523 NP_059993 NM_199139 NP_954590 NR_046396 NR_046397 NR_046398
Function	Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti- caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha- induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells. {ECO:0000269|PubMed:11175744, ECO:000
Subcellular Location	Isoform 5: Nucleus.
Tissue Specificity	Widely expressed. Expression is frequently down-regulated in cancer cell lines. Isoform 5 is widely expressed. Expressed in placenta (at protein level). {ECO:0000269|PubMed:11175744, ECO:0000269|PubMed:16343440, ECO:0000269|PubMed:17329253, ECO:0000269|PubMed:17570219}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human XAF1 full length protein - ab132187 from Abcam Category Protein Source Wheat germ Species Human

Human XAF1 peptide - ab39906 from Abcam Category Peptide Species Human

Human XAF1 peptide - ab39908 from Abcam Category Peptide Species Human

Human XAF1 protein fragment - ab153381 from Abcam Category Protein Source Wheat germ Species Human

Human XAF1 protein fragment - ab180297 from Abcam Category Protein Source E. coli Species Human

XAF1 peptide - ab110792 from Abcam Category Peptide

XAF1 Antibody Blocking Peptide - LS-E30097 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

XAF1 Antibody Blocking Peptide - LS-E30040 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

XAF1 Antibody Blocking Peptide - LS-E20759 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

XAF1 Antibody Blocking Peptide - LS-E20760 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

XAF1 Antibody Blocking Peptide - LS-E6559 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

XAF1 Recombinant Protein - H00054739-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

XAF1 Partial Recombinant Protein - H00054739-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

XAF1 Blocking Peptide - NBP1-76439PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

XAF1 Blocking Peptide - NBP1-76615PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

XAF1 Blocking Peptide - 33R-10885 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

XAF1 Blocking Peptide - 33R-8780 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

XAF1 Blocking Peptide - 33R-8184 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

XAF1 protein (His tag) - 80R-3811 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

XAF1 (His-tag) - AR51498PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

XAF1 (His-tag) - AR51498PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

XAF1 - H00054739-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

XAF1 - H00054739-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

XAF1 - H00054739-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

XAF1 - H00054739-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

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