XAF1

Gene Symbol XAF1
Entrez Gene 54739
Alt Symbol BIRC4BP, HSXIAPAF1, XIAPAF1
Species Human
Gene Type protein-coding
Description XIAP associated factor 1
Other Description BIRC4 binding protein|BIRC4-binding protein|XIAP-associated factor 1
Swissprots A2T932 A8K9Y3 Q99982 A8K2L1 A2T931 Q6MZE8 Q8N557 Q6GPH4 D3DTM6
Accessions EAW90287 EAW90288 EAW90289 EAW90290 EAW90291 Q6GPH4 AK056908 BAG51823 AK091799 AK290276 BAF82965 AK292710 BAF85399 AK292848 BAF85537 BC032776 AAH32776 BC058017 BC073156 AAH73156 BM153640 BM459605 BM475564 BQ639060 BX648588 BX649188 CAE46206 EF028165 ABM74556 EF028166 ABM74557 X99699 CAA68030 XM_005256706 XP_005256763 XM_005256708 XP_005256765 XM_011523945 XP_011522247 XM_011523946 XP_011522248 XM_011523947 XP_011522249 XM_011523948 XP_011522250 XM_011523949 XP_011522251 XR_934053 XR_934054 XR_934055 XR_934057 NM_017523 NP_059993 NM_199139 NP_954590 NR_046396 NR_046397 NR_046398
Function Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti- caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha- induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells. {ECO:0000269|PubMed:11175744, ECO:000
Subcellular Location Isoform 5: Nucleus.
Tissue Specificity Widely expressed. Expression is frequently down-regulated in cancer cell lines. Isoform 5 is widely expressed. Expressed in placenta (at protein level). {ECO:0000269|PubMed:11175744, ECO:0000269|PubMed:16343440, ECO:0000269|PubMed:17329253, ECO:0000269|PubMed:17570219}.

XAF1 CRISPR/Cas9 KO Plasmid (h) - sc-402427 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

XAF1 HDR Plasmid (h) - sc-402427-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

XAF1 Double Nickase Plasmid (h) - sc-402427-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

XAF1 Double Nickase Plasmid (h2) - sc-402427-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

XAF1 CRISPR Activation Plasmid (h) - sc-402427-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

XAF1 CRISPR Activation Plasmid (h2) - sc-402427-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

XAF1 Lentiviral Activation Particles (h) - sc-402427-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

XAF1 Lentiviral Activation Particles (h2) - sc-402427-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

XAF1 siRNA (h) - sc-37511 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

XAF1 shRNA Plasmid (h) - sc-37511-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

XAF1 shRNA (h) Lentiviral Particles - sc-37511-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

XAF1 RNAi - H00054739-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU139681 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22947 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22947 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

XAF1 siRNA (Human) - CRJ0191 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

XAF1 RNAi - H00054739-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

XAF1 - MBS8204618 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

XAF1 shRNA Plasmid (Human) - CHJ0191 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

XAF1 miRNA 3'UTR clone - MiUTR4H-TG09916 from Creative biogene

Species Reactivities Human
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