Gene Symbol | RABEP1 |
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Entrez Gene | 9135 |
Alt Symbol | RAB5EP, RABPT5 |
Species | Human |
Gene Type | protein-coding |
Description | rabaptin, RAB GTPase binding effector protein 1 |
Other Description | neurocrescin|rab GTPase-binding effector protein 1|rabaptin-4|rabaptin-5|rabaptin-5alpha|renal carcinoma antigen NY-REN-17 |
Swissprots | O95369 Q8IVX3 Q15276 B2RAG7 |
Accessions | EAW90343 EAW90344 EAW90345 Q15276 AA873800 AF098638 AAC70781 AK297535 BAG59936 AK310932 AK314183 BAG36864 AL050211 AL120839 AL157499 BC018742 BC032435 AAH32435 BC041700 AAH41700 BC065242 BI666786 BM678290 BX103338 DB124187 DB169027 EB387308 X77723 X91141 CAA62580 XM_011524060 XP_011522362 XM_011524061 XP_011522363 NM_001083585 NP_001077054 NM_001291581 NP_001278510 NM_001291582 NP_001278511 NM_004703 NP_004694 |
Function | Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. {ECO:0000269|PubMed:10698684, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:12773381, ECO:0000269|PubMed:22841712, ECO:0000269|PubMed:8521472}. |
Subcellular Location | Cytoplasm. Early endosome. Recycling endosome. Cytoplasmic vesicle. |
Top Pathways | Endocytosis |
RABAPTIN-5 CRISPR/Cas9 KO Plasmid (h) - sc-403303 from Santa Cruz Biotechnology
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RABAPTIN-5 HDR Plasmid (h) - sc-403303-HDR from Santa Cruz Biotechnology
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RABAPTIN-5 Double Nickase Plasmid (h) - sc-403303-NIC from Santa Cruz Biotechnology
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RABAPTIN-5 Double Nickase Plasmid (h2) - sc-403303-NIC-2 from Santa Cruz Biotechnology
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RABAPTIN-5 CRISPR Activation Plasmid (h) - sc-403303-ACT from Santa Cruz Biotechnology
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RABAPTIN-5 CRISPR Activation Plasmid (h2) - sc-403303-ACT-2 from Santa Cruz Biotechnology
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RABAPTIN-5 Lentiviral Activation Particles (h) - sc-403303-LAC from Santa Cruz Biotechnology
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RABAPTIN-5 Lentiviral Activation Particles (h2) - sc-403303-LAC-2 from Santa Cruz Biotechnology
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RABAPTIN-5 siRNA (h) - sc-36349 from Santa Cruz Biotechnology
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RABAPTIN-5 shRNA Plasmid (h) - sc-36349-SH from Santa Cruz Biotechnology
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RABAPTIN-5 shRNA (h) Lentiviral Particles - sc-36349-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU073171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17873 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17873 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11585 from Sigma-Aldrich
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RABEP1 siRNA (Human) - CRH6042 from Cohesion Biosciences
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RABEP1 - MBS8203508 from MyBioSource
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shRNA set against Human RABEP1 (NM_004703.4) - SHH388668 from Creative biogene
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shRNA set against Human RABEP1(NM_001083585.1) - SHR160500 from Creative biogene
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shRNA set against Human RABEP1(NM_004703.4) - SHR160582 from Creative biogene
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RABEP1 shRNA Plasmid (Human) - CHH6042 from Cohesion Biosciences
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RABEP1 miRNA 3'UTR clone - MiUTR1H-08578 from Creative biogene
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RABEP1 miRNA 3'UTR clone - MiUTR1H-08579 from Creative biogene
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