| Gene Symbol |
PLA2G15
|
| Entrez Gene |
23659
|
| Alt Symbol |
ACS, GXVPLA2, LLPL, LPLA2, LYPLA3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phospholipase A2, group XV
|
| Other Description |
1-O-acylceramide synthase|LCAT-like lysophospholipase|group XV phospholipase A2|lysophospholipase 3 (lysosomal phospholipase A2)|lysosomal phospholipase A2
|
| Swissprots |
Q9Y2B3 Q53GZ1 B3KMF3 Q9NPQ6 B4DUD1 Q8NCC3 Q9UG04
|
| Accessions |
EAW83217 EAW83218 Q8NCC3 AB017494 BAA76877 AK001705 BAG50965 AK074828 BAC11233 AK127898 AK222790 BAD96510 AK296263 BAG58976 AK298494 BAG60702 AK300596 BAG62293 AL110209 CAB53675 AL389957 CAB97531 AY358425 AAQ88791 BC011640 AAH11640 BC062605 AAH62605 EU832326 ACE87583 XM_005255886 XP_005255943 XM_011522979 XP_011521281 XM_011522980 XP_011521282 NM_012320 NP_036452
|
| Function |
Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N- acetylsphingosine and the concomitant release of a lyso- phospholipid (By similarity). May have weak lysophospholipase activity. {ECO:0000250}.
|
| Subcellular Location |
Lysosome {ECO:0000250}. Secreted {ECO:0000269|PubMed:10092508}.
|
| Tissue Specificity |
Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:10092508}.
|
| Top Pathways |
Lysosome, Glycerophospholipid metabolism
|
![Western Blot: LYPLA3 Overexpression Lysate (Adult Normal) [NBL1-12762] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LYPLA3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1527_LYPLA3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12762-img0002.jpg)