| Gene Symbol |
RTCA
|
| Entrez Gene |
8634
|
| Alt Symbol |
RPC, RTC1, RTCD1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RNA 3'-terminal phosphate cyclase
|
| Other Description |
RNA terminal phosphate cyclase domain 1|RNA terminal phosphate cyclase domain-containing protein 1|RTC domain-containing protein 1
|
| Swissprots |
Q5VVL6 Q96E99 Q5VVL5 O00442
|
| Accessions |
CAA72365 EAW72961 EAW72962 O00442 AI587400 AK292366 BAF85055 AK299793 BAG61672 AK307445 AK309394 AU310497 BC012604 AAH12604 CA437545 CF141820 DA361597 DB576272 JF432517 ADZ15734 Y11651 CAA72364 XM_005271298 XP_005271355 XM_005271299 XP_005271356 NM_001130841 NP_001124313 NM_003729 NP_003720
|
| Function |
Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA- N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'- phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
|
| Subcellular Location |
Nucleus, nucleoplasm.
|
| Tissue Specificity |
Ubiquitous.
|
