| Gene Symbol |
GRB7
|
| Entrez Gene |
2886
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
growth factor receptor-bound protein 7
|
| Other Description |
B47|GRB7 adapter protein|epidermal growth factor receptor GRB-7
|
| Swissprots |
Q92568 Q53YD3 B3KNL0 B7WP75 B3KWP9 J3KQM4 Q14451 B2RAV1 Q96DF9 Q9Y220
|
| Accessions |
AAG25938 EAW60600 EAW60601 Q14451 AB008789 BAA29059 AB008790 BAA29060 AK027729 BAG51372 AK125544 BAG54211 AK222849 BAD96569 AK222870 BAD96590 AK290115 BAF82804 AK294620 BAG57803 AK314368 BAG36998 AU124875 BC006535 AAH06535 BE247550 BT006686 AAP35332 D43772 BAA07827 D87513 BAA13412 DC384178 DQ893861 ABM84787 EU176171 ABW03622 XM_011524683 XP_011522985 NM_001030002 NP_001025173 NM_001242442 NP_001229371 NM_001242443 NP_001229372 NM_005310 NP_005301
|
| Function |
Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic granule {ECO:0000250}. Cell projection. Note=Predominantly cytoplasmic. Detected in stress granules, where mRNA is stored under stress conditions (By similarity). {ECO:0000250}.
|
![Western Blot: GRB7 Overexpression Lysate (Adult Normal) [NBL1-11327] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GRB7.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8211_GRB7%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11327-img0002.jpg)