GRB7

Gene Symbol GRB7
Entrez Gene 2886
Alt Symbol -
Species Human
Gene Type protein-coding
Description growth factor receptor-bound protein 7
Other Description B47|GRB7 adapter protein|epidermal growth factor receptor GRB-7
Swissprots Q92568 Q53YD3 B3KNL0 B7WP75 B3KWP9 J3KQM4 Q14451 B2RAV1 Q96DF9 Q9Y220
Accessions AAG25938 EAW60600 EAW60601 Q14451 AB008789 BAA29059 AB008790 BAA29060 AK027729 BAG51372 AK125544 BAG54211 AK222849 BAD96569 AK222870 BAD96590 AK290115 BAF82804 AK294620 BAG57803 AK314368 BAG36998 AU124875 BC006535 AAH06535 BE247550 BT006686 AAP35332 D43772 BAA07827 D87513 BAA13412 DC384178 DQ893861 ABM84787 EU176171 ABW03622 XM_011524683 XP_011522985 NM_001030002 NP_001025173 NM_001242442 NP_001229371 NM_001242443 NP_001229372 NM_005310 NP_005301
Function Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm. Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic granule {ECO:0000250}. Cell projection. Note=Predominantly cytoplasmic. Detected in stress granules, where mRNA is stored under stress conditions (By similarity). {ECO:0000250}.

GRB7 (A-12) - sc-376069 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GRB7 (A-12): sc-376069. Western blot analysis of GRB7 expression in EGF treated A-431 (A) and Hep G2 (B) whole cell lysates.

GRB7 (B-9) - sc-373982 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GRB7 (B-9): sc-373982. Western blot analysis of GRB7 expression in EGF treated A-431 whole cell lysate.

GRB7 (N-20) - sc-607 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
GRB7 (N-20): sc-607. Western blot analysis of GRB7 expression in non-transfected: sc-117752 (A) and mouse GRB7 transfected: sc-125418 (B) 293T whole cell lysates.

GRB7 (C-20) - sc-606 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
GRB7 (C-20): sc-606. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse ovary tissue showing membrane and cytoplasmic localization.

GRB7 (H-70) - sc-13954 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
GRB7 (H-70): sc-13954. Western blot analysis of GRB7 expression in untreated (A) and EGF-treated (B) A-431 whole cell lysates.

Anti-GRB7 antibody - ab191084 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GRB7 antibody (ab191084) at 0.5 µg/mlLane 1 : Rat testis tissue lysateLane 2 : SMMC whole cell lysateLane 3 : HeLa whole cell lysateLane 4 : A549 whole cell lysateLane 5 : SW620 whole cell lysateLysates/proteins at 40 µg per lane.

Anti-GRB7 antibody - ab103623 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-GRB7 antibody (ab103623) at 1 µg/ml + Mouse speen tissue lysate at 50 µg

Anti-GRB7 antibody - ab2630 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-GRB7 antibody - ab196295 from Abcam

Prices $370.00
Sizes 250 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GRB7 antibody (ab196295) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : A431 cell lysate

Anti-GRB7 antibody [EPR14099] - ab183737 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14099
Immunohistochemical analysis of paraffin-embedded Mouse brain tissue labeling GRB7 with ab183737 at 1/1000 dilution. Counter stain Hematoxylin.

Anti-GRB7 antibody [EPR4378] - ab109618 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4378
All lanes : Anti-GRB7 antibody [EPR4378] (ab109618) at 1/1000 dilutionLane 1 : SKBR-3 cell lysateLane 2 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP-labelled Goat anti-Rabbit at 1/2000 dilution

Anti-GRB7 antibody [EPR6858] - ab129091 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6858
Anti-GRB7 antibody [EPR6858] (ab129091) at 1/1000 dilution + SKBR-3 cell lysate at 10 µgSecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-GRB7 antibody - Aminoterminal end - ab55974 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GRB7 Antibody (C-Terminus) - LS-C46822 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GRB7 Antibody (N-Terminus) - LS-C46971 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GRB7 Antibody (aa1-532) - LS-C129439 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GRB7 Antibody (aa289-318, Biotin) - LS-C235966 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRB7 Antibody (aa289-318, AP) - LS-C235967 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRB7 Antibody (aa289-318, FITC) - LS-C235968 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRB7 Antibody (aa289-318, APC) - LS-C235969 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRB7 Antibody (aa289-318, PE) - LS-C235974 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRB7 Antibody (aa289-318, Azide-free, HRP) - LS-C249132 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRB7 Antibody (aa298-489, Biotin) - LS-C297583 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GRB7 Antibody (aa66-327, Biotin) - LS-C301024 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GRB7 Antibody (aa298-489, FITC) - LS-C303533 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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