FES

Gene Symbol FES
Entrez Gene 2242
Alt Symbol FPS
Species Human
Gene Type protein-coding
Description FES proto-oncogene, tyrosine kinase
Other Description Oncogene FES, feline sarcoma virus|feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog|feline sarcoma oncogene|feline sarcoma/Fujinami avian sarcoma oncogene homolog|p93c-fes|proto-oncogene c-Fes|proto-oncogene c-Fps|proto-oncogene tyrosine-protein kinase Fes/Fps|tyrosine-protein kinase Fes/Fps
Swissprots E9PC94 B4DUD0 Q6GTU5 P07332 B2R6E6 Q2VXS8 E9PC95 Q2VXT0 Q2VXS7
Accessions AAA53105 CAA29619 EAX02113 EAX02114 EAX02115 EAX02116 P07332 AK300595 BAG62292 AK300605 BAG62301 AK309530 AK312545 BAG35443 AY513654 AAS82866 AY513655 AAS82867 AY513656 AAS82868 AY513657 AAS82869 BC035357 AAH35357 DA782386 DB264752 DQ891350 ABM82276 DQ894530 ABM85456 M14209 AAA52441 X52192 CAA36438 XM_005254880 XP_005254937 XM_005254882 XP_005254939 XM_011521359 XP_011519661 XM_011521360 XP_011519662 XM_011521361 XP_011519663 XM_011521362 XP_011519664 XR_243205 XR_243206 XR_931768 NM_001143783 NP_001137255 NM_001143784 NP_001137256 NM_001143785 NP_001137257 NM_002005 NP_001996
Function Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down- stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. {ECO:0000269|PubMed:11509660, ECO:0000269|PubMed:15302586, ECO:0000269|PubMed:15485904, ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:17595334, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:19001085, ECO:0000269|PubMe
Subcellular Location Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion. Note=Distributed throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular membrane structures in the cytoplasm and at the cell periphery.
Tissue Specificity Widely expressed. Detected in adult colon epithelium. {ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:19051325}.
Top Pathways Axon guidance

Fes Antibody - 2736 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of HEL and UT-7 cell lysates, using Fes Antibody.

Fes (D-9) - sc-377179 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fes (D-9): sc-377179. Western blot analysis of Fes expression in non-transfected: sc-117752 (A) and human Fes transfected: sc-159705 (B) 293T whole cell lysates.

Fes (E-1) - sc-166371 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fes (E-1): sc-166371. Western blot analysis of Fes expression in non-transfected: sc-117752 (A) and human Fes transfected: sc-114396 (B) 293T whole cell lysates.

Fes (5A11G5) - sc-81706 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fes (5A11G5): sc-81706. Western blot analysis of truncated human recombinant Fes protein.

Fes (H-65) - sc-25415 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Fes (H-65): sc-25415. Western blot analysis of Fes expression in mouse heart (A) and rat heart (B) tissue extracts.

Fes (N-19) - sc-7671 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Fes (N-19): sc-7671. Western blot analysis of Fes expression in rat heart extract.

Fes (2E3G3) - sc-81704 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fes (2E3G3): sc-81704. Western blot analysis of truncated human recombinant Fes protein.

Fes (C-19) - sc-7670 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Fes (C-19): sc-7670. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing cytoplasmic and membrane staining of cells in seminiferous ducts and cytoplasmic staining of Leydig cells.

Anti-FES antibody - ab73137 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FES antibody - ab54675 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-FES antibody - ab151763 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FES antibody [5A11G5] - ab66385 from Abcam

Host Mouse
Clonality Monoclonal
Clone 5A11G5
All lanes : Anti-FES antibody [5A11G5] (ab66385) at 1/500 dilutionLane 1 : Molecular weight markersLane 2 : Truncated FES-His recombinant protein

Anti-FES antibody [EPR3229] - ab124726 from Abcam

Prices $304.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3229
All lanes : Anti-FES antibody [EPR3229] (ab124726) at 1/1000 dilutionLane 1 : TF1 cell lysateLane 2 : Human fetal kidney cell lysateLane 3 : U937 cell lysate Lysates/proteins at 10 µg per lane.

Anti-FES antibody [EPR3230(2)] - ab108418 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3230(2)
All lanes : Anti-FES antibody [EPR3230(2)] (ab108418) at 1/1000 dilutionLane 1 : TF-1 lysateLane 2 : U937 lysateLane 3 : Human spleen lysateLysates/proteins at 10 µg per lane.

Anti-FES antibody - Aminoterminal end - ab71681 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-FES antibody - Aminoterminal end (ab71681) at 1/100 dilution + HL-60 cell lysate at 12.5 µgSecondaryHRP-anti-rabbit

Anti-FES Antibody (Lys161) - LS-C177010 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of Fes (K161) pAb in paraffin-embedded human liver carcinoma tissue.

Anti-FES Antibody (clone 3A3-1E5) - LS-C197212 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3A3-1E5
Western Blot analysis of FES expression in transfected 293T cell line by FES monoclonal antibody (M01), clone 3A3-1E5.Lane 1: FES transfected lysate(93 KDa).Lane 2: Non-transfected lysate.

Anti-FES Antibody (Internal, clone EPR3230(2)) - LS-C138054 from LifeSpan Bioscience

Prices $450.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3230(2)
Immunofluorescent staining of HeLa cells using anti-FES antibody.

Anti-FES Antibody - LS-C143835 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-FES Antibody (aa1-823, clone 10C228, Azide-free) - LS-C183621 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 10C228

Anti-FES Antibody - LS-C144680 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FES Antibody (aa808-822) - LS-C312993 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FES Antibody (aa112-161) - LS-C291947 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FES Antibody - LS-C341204 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FES Antibody (aa644-663) - LS-C343903 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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