FES

Gene Symbol	FES
Entrez Gene	2242
Alt Symbol	FPS
Species	Human
Gene Type	protein-coding
Description	FES proto-oncogene, tyrosine kinase
Other Description	Oncogene FES, feline sarcoma virus|feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog|feline sarcoma oncogene|feline sarcoma/Fujinami avian sarcoma oncogene homolog|p93c-fes|proto-oncogene c-Fes|proto-oncogene c-Fps|proto-oncogene tyrosine-protein kinase Fes/Fps|tyrosine-protein kinase Fes/Fps
Swissprots	E9PC94 B4DUD0 Q6GTU5 P07332 B2R6E6 Q2VXS8 E9PC95 Q2VXT0 Q2VXS7
Accessions	AAA53105 CAA29619 EAX02113 EAX02114 EAX02115 EAX02116 P07332 AK300595 BAG62292 AK300605 BAG62301 AK309530 AK312545 BAG35443 AY513654 AAS82866 AY513655 AAS82867 AY513656 AAS82868 AY513657 AAS82869 BC035357 AAH35357 DA782386 DB264752 DQ891350 ABM82276 DQ894530 ABM85456 M14209 AAA52441 X52192 CAA36438 XM_005254880 XP_005254937 XM_005254882 XP_005254939 XM_011521359 XP_011519661 XM_011521360 XP_011519662 XM_011521361 XP_011519663 XM_011521362 XP_011519664 XR_243205 XR_243206 XR_931768 NM_001143783 NP_001137255 NM_001143784 NP_001137256 NM_001143785 NP_001137257 NM_002005 NP_001996
Function	Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down- stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. {ECO:0000269|PubMed:11509660, ECO:0000269|PubMed:15302586, ECO:0000269|PubMed:15485904, ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:17595334, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:19001085, ECO:0000269|PubMe
Subcellular Location	Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion. Note=Distributed throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular membrane structures in the cytoplasm and at the cell periphery.
Tissue Specificity	Widely expressed. Detected in adult colon epithelium. {ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:19051325}.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human FES full length protein - ab196084 from Abcam Category Protein Prices $612.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human FES full length protein - ab51411 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human FES full length protein - ab158431 from Abcam Category Protein Source Wheat germ Species Human

FES Antibody Blocking Peptide - LS-E19670 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FES Antibody Blocking Peptide - LS-E19671 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Fes Recombinant Protein - H00002242-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

Recombinant Human Fes Protein - P3861 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Source Insect Species Human

Fes Peptide - P2749 from Novus Biologicals Category Peptide Species Human

FES-Antibody-N-term-Blocking-Peptide - BP7705a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FES Blocking Peptide - 33R-1466 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

c-Fes - H00002242-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Source in vitro transl. Species Human

c-Fes - P3861 from Acris Antibodies Category Protein Prices $1,230.00 Sizes 5 µg Species Human

FES fusion protein - ag14641 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

FES fusion protein - ag3996 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

FES, Active Human Recombinant Protein - GWB-PS9783 from Genway Biotech Category Protein Prices $410.00 Sizes 10 µg Species Human

Recombinant Human Feline Sarcoma Oncogene, GST-tagged, Active - FES-311H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human FES, His & GST tagged - FES-902H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human FES (Active), GST-tagged - FES-1404H from Creative Biomart Category Protein Source Sf9 Cells Species Human

HSPBP1 1-362aa - CMB-387 from Reagent Proteins Category Protein Prices $469.00, $889.00 Sizes 50.00 µg, 250.00 µg Source E.coli Species Human

Recombinant Feline Sarcoma Oncogene (FES) - RPJ109Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Feline Sarcoma Oncogene (FES) - RPJ109Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Fes (K161) Peptide - BS2464P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Tyrosine-protein kinase Fes/Fps(FES) ,partial - CSB-YP008597HU CSB-EP008597HU CSB-BP008597HU CSB-MP008597HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Fes Recombinant Protein Antigen - NBP1-83429PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

c-FER Blocking Peptide - abx061052 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Dog, Monkey, Pig

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