| Gene Symbol | FES |
|---|---|
| Entrez Gene | 2242 |
| Alt Symbol | FPS |
| Species | Human |
| Gene Type | protein-coding |
| Description | FES proto-oncogene, tyrosine kinase |
| Other Description | Oncogene FES, feline sarcoma virus|feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog|feline sarcoma oncogene|feline sarcoma/Fujinami avian sarcoma oncogene homolog|p93c-fes|proto-oncogene c-Fes|proto-oncogene c-Fps|proto-oncogene tyrosine-protein kinase Fes/Fps|tyrosine-protein kinase Fes/Fps |
| Swissprots | E9PC94 B4DUD0 Q6GTU5 P07332 B2R6E6 Q2VXS8 E9PC95 Q2VXT0 Q2VXS7 |
| Accessions | AAA53105 CAA29619 EAX02113 EAX02114 EAX02115 EAX02116 P07332 AK300595 BAG62292 AK300605 BAG62301 AK309530 AK312545 BAG35443 AY513654 AAS82866 AY513655 AAS82867 AY513656 AAS82868 AY513657 AAS82869 BC035357 AAH35357 DA782386 DB264752 DQ891350 ABM82276 DQ894530 ABM85456 M14209 AAA52441 X52192 CAA36438 XM_005254880 XP_005254937 XM_005254882 XP_005254939 XM_011521359 XP_011519661 XM_011521360 XP_011519662 XM_011521361 XP_011519663 XM_011521362 XP_011519664 XR_243205 XR_243206 XR_931768 NM_001143783 NP_001137255 NM_001143784 NP_001137256 NM_001143785 NP_001137257 NM_002005 NP_001996 |
| Function | Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down- stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. {ECO:0000269|PubMed:11509660, ECO:0000269|PubMed:15302586, ECO:0000269|PubMed:15485904, ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:17595334, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:19001085, ECO:0000269|PubMe |
| Subcellular Location | Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion. Note=Distributed throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular membrane structures in the cytoplasm and at the cell periphery. |
| Tissue Specificity | Widely expressed. Detected in adult colon epithelium. {ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:19051325}. |
| Top Pathways | Axon guidance |
Fes CRISPR/Cas9 KO Plasmid (h) - sc-403246 from Santa Cruz Biotechnology
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Fes HDR Plasmid (h) - sc-403246-HDR from Santa Cruz Biotechnology
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Fes Double Nickase Plasmid (h) - sc-403246-NIC from Santa Cruz Biotechnology
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Fes Double Nickase Plasmid (h2) - sc-403246-NIC-2 from Santa Cruz Biotechnology
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Fes CRISPR Activation Plasmid (h) - sc-403246-ACT from Santa Cruz Biotechnology
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Fes CRISPR Activation Plasmid (h2) - sc-403246-ACT-2 from Santa Cruz Biotechnology
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Fes Lentiviral Activation Particles (h) - sc-403246-LAC from Santa Cruz Biotechnology
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Fes Lentiviral Activation Particles (h2) - sc-403246-LAC-2 from Santa Cruz Biotechnology
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Fes siRNA (h) - sc-35365 from Santa Cruz Biotechnology
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Fes shRNA Plasmid (h) - sc-35365-SH from Santa Cruz Biotechnology
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Fes shRNA (h) Lentiviral Particles - sc-35365-V from Santa Cruz Biotechnology
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Fes RNAi - H00002242-R02 from Novus Biologicals
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MISSION® esiRNA - EHU048771 from Sigma-Aldrich
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MISSION® siRNA - SIHK0763 from Sigma-Aldrich
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MISSION® siRNA - SIHK0762 from Sigma-Aldrich
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MISSION® siRNA - SIHK0764 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8628 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8628 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00949 from Sigma-Aldrich
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FES siRNA (Human) - CRH1562 from Cohesion Biosciences
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FES - MBS8214945 from MyBioSource
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Fes HDR Plasmid (h2) - sc-403246-HDR-2 from Santa Cruz Biotechnology
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Fes CRISPR/Cas9 KO Plasmid (h2) - sc-403246-KO-2 from Santa Cruz Biotechnology
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FES shRNA Plasmid (Human) - CHH1562 from Cohesion Biosciences
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