IQGAP1

Gene Symbol IQGAP1
Entrez Gene 8826
Alt Symbol HUMORFA01, SAR1, p195
Species Human
Gene Type protein-coding
Description IQ motif containing GTPase activating protein 1
Other Description RasGAP-like with IQ motifs|ras GTPase-activating-like protein IQGAP1
Swissprots P46940 A7MBM3
Accessions EAX02102 EAX02103 P46940 AF401205 AAL02166 AI924000 AK055054 AK125643 AK298000 BAG60306 AK304337 BAG65182 AK307643 AL110106 BC005906 AAH05906 BC016714 BC020549 AAH20549 BC037425 AAH37425 BC064971 AAH64971 BC089385 AAH89385 BC110811 AAI10812 BC139731 AAI39732 BC151834 AAI51835 D29640 BAA06123 XM_005254984 XP_005255041 NM_003870 NP_003861
Function Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. {ECO:0000269|PubMed:15695813}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:15355962}.
Tissue Specificity Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas.
Top Pathways Adherens junction, Proteoglycans in cancer, Regulation of actin cytoskeleton

IQGAP1 Antibody - 2293 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell types, using IQGAP1 Antibody.

IQGAP1 (D-3) - sc-374307 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IQGAP1 (D-3): sc-374307. Western blot analysis of IQGAP1 expression in TT (A) and KNRK (B) whole cell lysates.

IQGAP1 (F-7) - sc-376383 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IQGAP1 (F-7): sc-376383. Western blot analysis of IQGAP1 expression in KNRK whole cell lysate.

IQGAP1 (H-109) - sc-10792 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IQGAP1 (H-109): sc-10792. Western blot analysis of IQGAP1 expression in A549 (A) and Caki-1 (B) whole cell lysates.

IQGAP1 (N-17) - sc-8737 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IQGAP1 (N-17): sc-8737. Immunofluorescence staining of methanol-fixed A549 cells showing cytoplasmic and membrane localization.

IQGAP1 (C-9) - sc-376021 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IQGAP1 (C-9): sc-376021. Western blot analysis of IQGAP1 expression in C32 whole cell lysate.

IQGAP1 (C-17) - sc-8738 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IQGAP1 (C-17): sc-8738. Immunofluorescence staining of methanol-fixed A549 cells showing cytoplasmic localization.

Anti-IQGAP1 antibody - ab86064 from Abcam

Prices $394.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling IQGAP1 with ab86064 at 1/1000 (0.2µg/ml) and 1/200 (1µg/ml). Detection: DAB and a DyLight® 594-conjugated goat anti-rabbit IgG (H+L) (1/100).

Anti-IQGAP1 antibody - ab56529 from Abcam

Prices $394.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
IQGAP1 antibody (ab56529) used in immunohistochemistry at 1ug/ml on formalin fixed and paraffin embedded human salivary gland.

Anti-IQGAP1 antibody - ab110203 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab110203 stained MCF7 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab110203 1µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM. This antibody also gave a positive result in 4% foarmaldehyde fixed (10 min) Hek293 cells at 1µg/ml, and in 100% methanol fixed (5 min) HeLa and MCF7 cells at 1µg/ml.

Anti-IQGAP1 antibody - ab99471 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-IQGAP1 antibody (ab99471) at 1 µg/ml + Human kidney cell lysate at 35 µgdeveloped using the ECL technique

Anti-IQGAP1 antibody - ab87262 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab87262 at a 1/100 dilution staining IQGAP1 in Human breast carcinoma tissue.Detection: Goat anti-Rabbit IgG conjugated with a red-fluorescent dye, at a 1/100 dilution.

Anti-IQGAP1 antibody - ab136969 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-IQGAP1 antibody (ab136969) at 1/500 dilution + K562 cell lysate at 30 µg

Anti-IQGAP1 antibody [0.T.72] - ab33542 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 0.T.72

Anti-IQGAP1 antibody [EPR5220] - ab133490 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5220
All lanes : Anti-IQGAP1 antibody [EPR5220] (ab133490) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : 293T cell lysateLane 3 : Human placenta lysateLane 4 : Mouse thymus lysateLane 5 : F9 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-IQGAP1 antibody [EPR5221] - ab109292 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5221
All lanes : Anti-IQGAP1 antibody [EPR5221] (ab109292) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Cos-1 cell lysateLane 3 : HUVEC cell lysateLane 4 : Jurkat cell lysateLysates/proteins at 10 µg per lane.

Anti-SAR1 antibody [14A9C5] - ab170042 from Abcam

Prices $378.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 14A9C5
Anti-SAR1 antibody [14A9C5] (ab170042) at 1/100 dilution + EC-whole cell lysate

Anti-IQGAP1 Antibody (aa863-1657) - LS-C8229 from LifeSpan Bioscience

Prices $475.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-IQGAP1 Antibody (C-Terminus) - LS-C8231 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-IQGAP1 Antibody (aa256-285, AP) - LS-C260319 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IQGAP1 Antibody (aa256-285, APC) - LS-C260320 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IQGAP1 Antibody (aa256-285, Biotin) - LS-C260321 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IQGAP1 Antibody (aa256-285, FITC) - LS-C260322 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IQGAP1 Antibody (aa256-285, Azide-free, HRP) - LS-C260323 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IQGAP1 Antibody (aa256-285, PE) - LS-C260326 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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