| Gene Symbol |
IQGAP1
|
| Entrez Gene |
8826
|
| Alt Symbol |
HUMORFA01, SAR1, p195
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
IQ motif containing GTPase activating protein 1
|
| Other Description |
RasGAP-like with IQ motifs|ras GTPase-activating-like protein IQGAP1
|
| Swissprots |
P46940 A7MBM3
|
| Accessions |
EAX02102 EAX02103 P46940 AF401205 AAL02166 AI924000 AK055054 AK125643 AK298000 BAG60306 AK304337 BAG65182 AK307643 AL110106 BC005906 AAH05906 BC016714 BC020549 AAH20549 BC037425 AAH37425 BC064971 AAH64971 BC089385 AAH89385 BC110811 AAI10812 BC139731 AAI39732 BC151834 AAI51835 D29640 BAA06123 XM_005254984 XP_005255041 NM_003870 NP_003861
|
| Function |
Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. {ECO:0000269|PubMed:15695813}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:15355962}.
|
| Tissue Specificity |
Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas.
|
| Top Pathways |
Adherens junction, Proteoglycans in cancer, Regulation of actin cytoskeleton
|