MELK

Gene Symbol	MELK
Entrez Gene	9833
Alt Symbol	HPK38
Species	Human
Gene Type	protein-coding
Description	maternal embryonic leucine zipper kinase
Other Description	pEg3 kinase|protein kinase Eg3|protein kinase PK38|tyrosine-protein kinase MELK
Swissprots	Q7L3C3 A6P3A7 F5H689 F5H2R4 A6P3A8 B7Z6Y0 F5H0Y0 B7Z6Q7 B7Z5M5 B1AMQ6 B7Z1E6 B7Z7Q1 B7Z6R8 D3DRP8 Q14680
Accessions	CAL40334 CAL40335 CAL40336 CBL93957 CCB07557 CDH92804 EAW58302 EAW58303 EAW58304 Q14680 AB183427 BAF73615 AB183428 BAF73616 AB267395 BAF74635 AI590871 AK222811 BAD96531 AK293284 BAH11482 AK293423 BAH11502 AK293447 BAH11508 AK296820 BAH12436 AK299164 BAH12961 AK300761 BAH13343 AK300821 BAH13354 AK301131 BAH13416 AK302374 BAH13687 AK309470 BC014039 AAH14039 BP365611 D79997 BAA11492 DB368226 W01871 XM_011518076 XP_011516378 XM_011518077 XP_011516379 XM_011518078 XP_011516380 XM_011518079 XP_011516381 XM_011518080 XP_011516382 XM_011518081 XP_011516383 XM_011518082 XP_011516384 XM_011518083 XP_011516385 XM_011518084 XP_011516386 XM_011518085 XP_011516387 XM_011518086 XP_011516388 NM_001256685 NP_001243614 NM_001256687 NP_001243616 NM_001256688 NP_001243617 NM_001256689 NP_001243618 NM_001256690 NP_001243619 NM_001256691 NP_001243620 NM_001256692 NP_001243621 NM_001256693 NP_001243622 NM_014791 NP_055606 NR_046337
Function	Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:16159311, ECO:0000269|PubMed:21145462}; Peripheral membrane protein {ECO:0000269|PubMed:16159311, ECO:0000269|PubMed:21145462}.
Tissue Specificity	Expressed in placenta, kidney, thymus, testis, ovary and intestine. {ECO:0000269|PubMed:8724849}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MELK Antibody - 2274 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

MELK (E-14) - sc-48035 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MELK (N-19) - sc-48037 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MELK (H-16) - sc-48036 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MELK (H-24) - sc-130816 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

MELK (H-56) - sc-292832 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-MELK antibody - ab155767 from Abcam Prices $384.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MELK antibody - ab119330 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MELK antibody - ab9696 from Abcam Prices $378.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-MELK antibody - ab72703 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MELK antibody [2G2] - ab129373 from Abcam Prices $384.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2G2

Anti-MELK antibody [EPR3981] - ab108529 from Abcam Prices $381.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR3981

Anti-MELK antibody - C-terminal - ab71287 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MELK Antibody - LS-C189092 from LifeSpan Bioscience Prices $425.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-MELK Antibody (Internal, clone EPR3981) - LS-C137796 from LifeSpan Bioscience Prices $480.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR3981

Anti-MELK Antibody (aa639-651) - LS-C20179 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-MELK Antibody (aa432-481) - LS-C111095 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-MELK Antibody (Internal, AP) - LS-C279437 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MELK Antibody (aa525-554) - LS-C98361 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-MELK Antibody (aa626-630) - LS-C205193 from LifeSpan Bioscience Prices $265.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-MELK Antibody (Internal, APC) - LS-C279438 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MELK Antibody (aa201-230) - LS-C98360 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-MELK Antibody (aa431-480) - LS-C119044 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MELK Antibody (C-Terminus, AP) - LS-C279440 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MELK Antibody (Internal, Biotin) - LS-C279439 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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