| Gene Symbol |
MELK
|
| Entrez Gene |
9833
|
| Alt Symbol |
HPK38
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
maternal embryonic leucine zipper kinase
|
| Other Description |
pEg3 kinase|protein kinase Eg3|protein kinase PK38|tyrosine-protein kinase MELK
|
| Swissprots |
Q7L3C3 A6P3A7 F5H689 F5H2R4 A6P3A8 B7Z6Y0 F5H0Y0 B7Z6Q7 B7Z5M5 B1AMQ6 B7Z1E6 B7Z7Q1 B7Z6R8 D3DRP8 Q14680
|
| Accessions |
CAL40334 CAL40335 CAL40336 CBL93957 CCB07557 CDH92804 EAW58302 EAW58303 EAW58304 Q14680 AB183427 BAF73615 AB183428 BAF73616 AB267395 BAF74635 AI590871 AK222811 BAD96531 AK293284 BAH11482 AK293423 BAH11502 AK293447 BAH11508 AK296820 BAH12436 AK299164 BAH12961 AK300761 BAH13343 AK300821 BAH13354 AK301131 BAH13416 AK302374 BAH13687 AK309470 BC014039 AAH14039 BP365611 D79997 BAA11492 DB368226 W01871 XM_011518076 XP_011516378 XM_011518077 XP_011516379 XM_011518078 XP_011516380 XM_011518079 XP_011516381 XM_011518080 XP_011516382 XM_011518081 XP_011516383 XM_011518082 XP_011516384 XM_011518083 XP_011516385 XM_011518084 XP_011516386 XM_011518085 XP_011516387 XM_011518086 XP_011516388 NM_001256685 NP_001243614 NM_001256687 NP_001243616 NM_001256688 NP_001243617 NM_001256689 NP_001243618 NM_001256690 NP_001243619 NM_001256691 NP_001243620 NM_001256692 NP_001243621 NM_001256693 NP_001243622 NM_014791 NP_055606 NR_046337
|
| Function |
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:16159311, ECO:0000269|PubMed:21145462}; Peripheral membrane protein {ECO:0000269|PubMed:16159311, ECO:0000269|PubMed:21145462}.
|
| Tissue Specificity |
Expressed in placenta, kidney, thymus, testis, ovary and intestine. {ECO:0000269|PubMed:8724849}.
|
![Western Blot: MELK Overexpression Lysate (Adult Normal) [NBL1-13007] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MELK.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/12683_MELK%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-13007-img0002.jpg)