MELK

Gene Symbol	MELK
Entrez Gene	9833
Alt Symbol	HPK38
Species	Human
Gene Type	protein-coding
Description	maternal embryonic leucine zipper kinase
Other Description	pEg3 kinase|protein kinase Eg3|protein kinase PK38|tyrosine-protein kinase MELK
Swissprots	Q7L3C3 A6P3A7 F5H689 F5H2R4 A6P3A8 B7Z6Y0 F5H0Y0 B7Z6Q7 B7Z5M5 B1AMQ6 B7Z1E6 B7Z7Q1 B7Z6R8 D3DRP8 Q14680
Accessions	CAL40334 CAL40335 CAL40336 CBL93957 CCB07557 CDH92804 EAW58302 EAW58303 EAW58304 Q14680 AB183427 BAF73615 AB183428 BAF73616 AB267395 BAF74635 AI590871 AK222811 BAD96531 AK293284 BAH11482 AK293423 BAH11502 AK293447 BAH11508 AK296820 BAH12436 AK299164 BAH12961 AK300761 BAH13343 AK300821 BAH13354 AK301131 BAH13416 AK302374 BAH13687 AK309470 BC014039 AAH14039 BP365611 D79997 BAA11492 DB368226 W01871 XM_011518076 XP_011516378 XM_011518077 XP_011516379 XM_011518078 XP_011516380 XM_011518079 XP_011516381 XM_011518080 XP_011516382 XM_011518081 XP_011516383 XM_011518082 XP_011516384 XM_011518083 XP_011516385 XM_011518084 XP_011516386 XM_011518085 XP_011516387 XM_011518086 XP_011516388 NM_001256685 NP_001243614 NM_001256687 NP_001243616 NM_001256688 NP_001243617 NM_001256689 NP_001243618 NM_001256690 NP_001243619 NM_001256691 NP_001243620 NM_001256692 NP_001243621 NM_001256693 NP_001243622 NM_014791 NP_055606 NR_046337
Function	Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:16159311, ECO:0000269|PubMed:21145462}; Peripheral membrane protein {ECO:0000269|PubMed:16159311, ECO:0000269|PubMed:21145462}.
Tissue Specificity	Expressed in placenta, kidney, thymus, testis, ovary and intestine. {ECO:0000269|PubMed:8724849}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human MELK (mutated T460 M) protein fragment - ab179957 from Abcam Category Protein Prices $251.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human MELK protein fragment - ab102551 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Human MELK peptide - ab23158 from Abcam Category Peptide Species Human

Human MELK protein fragment - ab153020 from Abcam Category Protein Source Wheat germ Species Human

MELK Antibody Blocking Peptide - LS-E25204 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MELK Antibody Blocking Peptide - LS-E8722 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MELK Antibody Blocking Peptide - LS-E8721 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MELK Antibody Blocking Peptide - LS-E16852 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MELK Protein - H00009833-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MELK Recombinant Protein - P4722 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

MELK Peptide - P2305 from Novus Biologicals Category Peptide Species Human

MELK Peptide - P2304 from Novus Biologicals Category Peptide Species Human

MELK-Antibody-C-term-Blocking-Peptide - BP7149b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MELK-Antibody-Center-Blocking-Peptide - BP7149a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MELK blocking peptide - GTX89981-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Bovine

MELK Blocking Peptide - 33R-1602 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MELK Peptide - AC21-0025-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

MELK - H00009833-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MELK - H00009833-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MELK - P4722 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

MELK - P5785 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

MELK Peptide - 45-089P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

MELK fusion protein - ag1897 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

MELK fusion protein - Ag4381 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human Maternal Embryonic Leucine Zipper Kinase - MELK-730H from Creative Biomart Category Protein Source Baculovirus infected Sf9 cells.

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