| Gene Symbol |
NELFB
|
| Entrez Gene |
25920
|
| Alt Symbol |
COBRA1, NELF-B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
negative elongation factor complex member B
|
| Other Description |
cofactor of BRCA1|negative elongation factor B|negative elongation factor protein B
|
| Swissprots |
Q8WX92 Q96EW5 Q9Y3W0 Q9ULN8 Q9H9R4 A2BFA3
|
| Accessions |
EAW88377 EAW88378 Q8WX92 AB033008 BAA86496 AF464935 AAL69965 AK022651 BAB14157 AK091056 BAG52272 AL050280 CAB43381 AM393289 CAL38167 BC011892 AAH11892 BC019029 DA210427 NM_015456 NP_056271
|
| Function |
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. May be able to induce chromatin unfolding. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12612062}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11739404}.
|
| Tissue Specificity |
Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:12612062}.
|