| Gene Symbol |
MRGPRX2
|
| Entrez Gene |
117194
|
| Alt Symbol |
MGRG3, MRGX2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MAS-related GPR, member X2
|
| Other Description |
G protein-coupled receptor MRGX2|Mas-related G protein-coupled receptor G3|mas-related G-protein coupled receptor member X2
|
| Swissprots |
Q96LB1 Q4QXX7 Q4QXX4 W8W3L5 Q4QXX3 B5B0C7 Q4QXW7 Q4QXX0 Q4QXX2 Q4QXX6 Q4QXW4
|
| Accessions |
AAK91805 AAW70043 AAW70044 AAW70045 AAW70046 AAW70047 AAW70048 AAW70049 AAW70050 AAW70051 AAW70052 AAW70053 AAW70054 AAW70055 AAW70056 AAW70057 AAW70058 AAW70059 AAW70060 AAW70061 AAW70062 AAW70063 AAW70064 AAW70065 AAW70066 AAW70067 AAW70068 AAW70069 AAW70070 AAW70071 AAW70072 AAW70073 AAW70074 AAW70082 AAW70083 ACG60653 BAB89339 BAC06030 CDG86189 EAW68359 Q96LB1 BC063450 AAH63450 EU831808 ACE87326 EU831885 ACE86644 HY005030 XM_011519881 XP_011518183 NM_001303615 NP_001290544 NM_054030 NP_473371
|
| Function |
Mast cell-specific receptor for basic secretagogues (PubMed:25517090). Basic secretagogues are a set of cationic amphiphilic drugs, as well as endo- and exogenous peptides, which share basic head group combined with a hydrophobic core of the molecule. Recognizes and binds small molecules containing a cyclized a tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium (By similarity). Mediates mast cell responsiveness and side effects of small-molecule therapeutic drugs by acting as a specific receptor for basic secretagogues drugs in mast cells: binding to drugs induces pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of ligands, including peptides: acts as a receptor of cortistatin-14, a regulator of sleep regulation locomotor activity, and cortical function (PubMed:12915402). Acts as a receptor for proadrenomedullin
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein {ECO:0000255}.
|
| Tissue Specificity |
Mainly expressed in mast cells. Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion (PubMed:12915402). Detected in blood vessels, scattered lymphocytes, and gastrointestinal ganglia (at protein level) (PubMed:16161007). {ECO:0000269|PubMed:12915402, ECO:0000269|PubMed:16161007}.
|