MRGPRX2

Gene Symbol	MRGPRX2
Entrez Gene	117194
Alt Symbol	MGRG3, MRGX2
Species	Human
Gene Type	protein-coding
Description	MAS-related GPR, member X2
Other Description	G protein-coupled receptor MRGX2|Mas-related G protein-coupled receptor G3|mas-related G-protein coupled receptor member X2
Swissprots	Q96LB1 Q4QXX7 Q4QXX4 W8W3L5 Q4QXX3 B5B0C7 Q4QXW7 Q4QXX0 Q4QXX2 Q4QXX6 Q4QXW4
Accessions	AAK91805 AAW70043 AAW70044 AAW70045 AAW70046 AAW70047 AAW70048 AAW70049 AAW70050 AAW70051 AAW70052 AAW70053 AAW70054 AAW70055 AAW70056 AAW70057 AAW70058 AAW70059 AAW70060 AAW70061 AAW70062 AAW70063 AAW70064 AAW70065 AAW70066 AAW70067 AAW70068 AAW70069 AAW70070 AAW70071 AAW70072 AAW70073 AAW70074 AAW70082 AAW70083 ACG60653 BAB89339 BAC06030 CDG86189 EAW68359 Q96LB1 BC063450 AAH63450 EU831808 ACE87326 EU831885 ACE86644 HY005030 XM_011519881 XP_011518183 NM_001303615 NP_001290544 NM_054030 NP_473371
Function	Mast cell-specific receptor for basic secretagogues (PubMed:25517090). Basic secretagogues are a set of cationic amphiphilic drugs, as well as endo- and exogenous peptides, which share basic head group combined with a hydrophobic core of the molecule. Recognizes and binds small molecules containing a cyclized a tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium (By similarity). Mediates mast cell responsiveness and side effects of small-molecule therapeutic drugs by acting as a specific receptor for basic secretagogues drugs in mast cells: binding to drugs induces pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of ligands, including peptides: acts as a receptor of cortistatin-14, a regulator of sleep regulation locomotor activity, and cortical function (PubMed:12915402). Acts as a receptor for proadrenomedullin
Subcellular Location	Cell membrane; Multi-pass membrane protein {ECO:0000255}.
Tissue Specificity	Mainly expressed in mast cells. Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion (PubMed:12915402). Detected in blood vessels, scattered lymphocytes, and gastrointestinal ganglia (at protein level) (PubMed:16161007). {ECO:0000269|PubMed:12915402, ECO:0000269|PubMed:16161007}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MRGX2 (C-17) - sc-69585 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MRGX2 (N-17) - sc-69586 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

pan MRGX (F-1) - sc-393652 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Anti-GPCR MRGX2 antibody - ab65429 from Abcam Host Rabbit Clonality Polyclonal

Anti-GPCR MRGX2 antibody - ab129548 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-GPCR MRGX2 antibody - ab188767 from Abcam Prices $407.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-GPCR MRGX2 antibody - ab116712 from Abcam Prices $407.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-GPCR MRGX2 antibody [1D3] - ab167125 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 1D3

Anti-MRGPRX2 / MRGX2 Antibody (aa287-315) IHC-plus™ - LS-B11741 from LifeSpan Bioscience Prices $395.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MRGPRX2 / MRGX2 Antibody (aa286-316, AP) - LS-C237762 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MRGPRX2 / MRGX2 Antibody (aa286-316, APC) - LS-C237763 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MRGPRX2 / MRGX2 Antibody (aa286-316, Biotin) - LS-C237764 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MRGPRX2 / MRGX2 Antibody (aa286-316, FITC) - LS-C237765 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MRGPRX2 / MRGX2 Antibody (aa286-316, PE) - LS-C237770 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MRGPRX2 / MRGX2 Antibody (aa286-316, Azide-free, HRP) - LS-C248844 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MRGPRX2 / MRGX2 Antibody - LS-C309062 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-MRGPRX2 / MRGX2 Antibody (aa286-316) - LS-C323099 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MRGPRX2 / MRGX2 Antibody (aa149-198) - LS-C135658 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-MRGPRX2 / MRGX2 Antibody (C-Terminus) IHC-plus™ - LS-A2750 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-MRGPRX2 / MRGX2 Antibody (Extracellular Domain) IHC-plus™ - LS-A6645 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-MRGPRX2 / MRGX2 Antibody (Extracellular Domain) IHC-plus™ - LS-A6644 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-MRGPRX2 / MRGX2 Antibody (C-Terminus) IHC-plus™ - LS-A6647 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

MRGX2 Antibody (477533) [Unconjugated] - MAB4727 from Novus Biologicals Prices $99.00, $249.00 Sizes 25 µg, 100 µg Host Mouse Clonality Monoclonal Clone 477533

MRGX2 Antibody - NBP2-33744 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MRGX2 Antibody - NLS2750 from Novus Biologicals Prices $329.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

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