MRGPRX2

Gene Symbol MRGPRX2
Entrez Gene 117194
Alt Symbol MGRG3, MRGX2
Species Human
Gene Type protein-coding
Description MAS-related GPR, member X2
Other Description G protein-coupled receptor MRGX2|Mas-related G protein-coupled receptor G3|mas-related G-protein coupled receptor member X2
Swissprots Q96LB1 Q4QXX7 Q4QXX4 W8W3L5 Q4QXX3 B5B0C7 Q4QXW7 Q4QXX0 Q4QXX2 Q4QXX6 Q4QXW4
Accessions AAK91805 AAW70043 AAW70044 AAW70045 AAW70046 AAW70047 AAW70048 AAW70049 AAW70050 AAW70051 AAW70052 AAW70053 AAW70054 AAW70055 AAW70056 AAW70057 AAW70058 AAW70059 AAW70060 AAW70061 AAW70062 AAW70063 AAW70064 AAW70065 AAW70066 AAW70067 AAW70068 AAW70069 AAW70070 AAW70071 AAW70072 AAW70073 AAW70074 AAW70082 AAW70083 ACG60653 BAB89339 BAC06030 CDG86189 EAW68359 Q96LB1 BC063450 AAH63450 EU831808 ACE87326 EU831885 ACE86644 HY005030 XM_011519881 XP_011518183 NM_001303615 NP_001290544 NM_054030 NP_473371
Function Mast cell-specific receptor for basic secretagogues (PubMed:25517090). Basic secretagogues are a set of cationic amphiphilic drugs, as well as endo- and exogenous peptides, which share basic head group combined with a hydrophobic core of the molecule. Recognizes and binds small molecules containing a cyclized a tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium (By similarity). Mediates mast cell responsiveness and side effects of small-molecule therapeutic drugs by acting as a specific receptor for basic secretagogues drugs in mast cells: binding to drugs induces pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of ligands, including peptides: acts as a receptor of cortistatin-14, a regulator of sleep regulation locomotor activity, and cortical function (PubMed:12915402). Acts as a receptor for proadrenomedullin
Subcellular Location Cell membrane; Multi-pass membrane protein {ECO:0000255}.
Tissue Specificity Mainly expressed in mast cells. Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion (PubMed:12915402). Detected in blood vessels, scattered lymphocytes, and gastrointestinal ganglia (at protein level) (PubMed:16161007). {ECO:0000269|PubMed:12915402, ECO:0000269|PubMed:16161007}.

MRGX2 CRISPR/Cas9 KO Plasmid (h) - sc-414107 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRGX2 HDR Plasmid (h) - sc-414107-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRGX2 Double Nickase Plasmid (h) - sc-414107-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRGX2 Double Nickase Plasmid (h2) - sc-414107-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRGX2 CRISPR Activation Plasmid (h) - sc-414107-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRGX2 CRISPR Activation Plasmid (h2) - sc-414107-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRGX2 Lentiviral Activation Particles (h) - sc-414107-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRGX2 Lentiviral Activation Particles (h2) - sc-414107-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRGX2 siRNA (h) - sc-75823 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MRGX2 shRNA Plasmid (h) - sc-75823-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MRGX2 shRNA (h) Lentiviral Particles - sc-75823-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MRGX2 RNAi - H00117194-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU145411 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14537 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14537 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07736 from Sigma-Aldrich

Category miRNA

MRGPRX2 siRNA (Human) - CRJ4559 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MRGPRX2 (NM_054030.2) - SHH344424 from Creative biogene

Category siRNA
Species Reactivities Human

Human MRGPRX2 siRNA - orb275060 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MRGPRX2 shRNA Plasmid (Human) - CHJ4559 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MRGPRX2 miRNA 3'UTR clone - MiUTR1H-06421 from Creative biogene

Species Reactivities Human
Search more