| Gene Symbol |
GPR132
|
| Entrez Gene |
29933
|
| Alt Symbol |
G2A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
G protein-coupled receptor 132
|
| Other Description |
G2 accumulation protein|probable G-protein coupled receptor 132
|
| Swissprots |
Q9UNW8 B4E144 A8K7X7 Q9BSU2
|
| Accessions |
CAH25932 CAH25933 EAW81898 Q9UNW8 AA714520 AB465599 BAG84609 AB465600 BAG84610 AF083955 AAD47380 AK292142 BAF84831 AK303654 BAG64656 AX775841 CAE11620 AX775935 CAE11667 AX775939 CAE11669 BC004555 BC084546 AAH84546 BT007257 AAP35921 DB137292 EU432121 ABY87920 EU543705 ACC61682 W15172 NM_001278694 NP_001265623 NM_001278695 NP_001265624 NM_001278696 NP_001265625 NM_013345 NP_037477
|
| Function |
May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9- hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton- sensing activity. {ECO:0000269|PubMed:12586833, ECO:0000269|PubMed:19855098, ECO:0000269|PubMed:9770487}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and thymus. Weakly expressed in heart and lung. In atherosclerotic plaques, expression is observed around the lipid core and at the shoulder region. {ECO:0000269|PubMed:12482833}.
|