| Gene Symbol |
DEFA3
|
| Entrez Gene |
1668
|
| Alt Symbol |
DEF3, HNP-3, HNP3, HP-3, HP3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
defensin, alpha 3, neutrophil-specific
|
| Other Description |
defensin 3, neutrophil-specific|neutrophil defensin 3|neutrophil peptide 3
|
| Swissprots |
P59666
|
| Accessions |
AAB57722 AAT68881 AAT68885 CAM91150 P59666 BC027917 AAH27917 BC119706 AAI19707 EU176174 ABW03625 M21131 AAA35753 M23281 AAA52304 X13621 CAA31952 XM_011534741 XP_011533043 NM_005217 NP_005208
|
| Function |
Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. {ECO:0000269|PubMed:15616305, ECO:0000269|PubMed:15894545, ECO:0000269|PubMed:17452329, ECO:0000269|PubMed:2006422}.
|
| Subcellular Location |
Secreted.
|
| Top Pathways |
Transcriptional misregulation in cancer
|
