| Gene Symbol | CREB3L4 |
|---|---|
| Entrez Gene | 148327 |
| Alt Symbol | AIBZIP, ATCE1, CREB3, CREB4, JAL, hJAL |
| Species | Human |
| Gene Type | protein-coding |
| Description | cAMP responsive element binding protein 3-like 4 |
| Other Description | CREB-4|androgen-induced basic leucine zipper protein|attaching to CRE-like 1|cAMP responsive element binding protein 1|cAMP-responsive element-binding protein 3-like protein 4|cAMP-responsive element-binding protein 4|cyclic AMP-responsive element-binding protein 3-like protein 4|cyclic AMP-responsive element-binding protein 4|tisp40|transcript induced in spermiogenesis protein 40 |
| Swissprots | Q8TEY5 Q5T4L0 Q86YW6 D3DV62 |
| Accessions | BAC45224 EAW53251 EAW53252 EAW53253 EAW53254 EAW53255 EAW53256 EAW53257 EAW53258 Q8TEY5 AA652478 AB052778 BAC45035 AF394167 AAL76113 AF468007 AAO33070 AK297703 BAG60061 AK304259 BAG65125 AK304665 BAG65440 AK309767 AY049977 AAL13157 BC038962 AAH38962 BF681098 BX647716 DB012316 EU446885 ABZ92414 EU832796 ACE87807 EU832838 ACE87849 GQ129234 ACT64368 GQ129341 ACT64475 XM_006711172 XP_006711235 NM_001255978 NP_001242907 NM_001255979 NP_001242908 NM_001255980 NP_001242909 NM_001255981 NP_001242910 NM_130898 NP_570968 NR_045658 |
| Function | Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity). {ECO:0000250}. |
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=May also be located in Golgi apparatus. |
| Tissue Specificity | According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus. {ECO:0000269|PubMed:11830526, ECO:0000269|PubMed:12111373, ECO:0000269|PubMed:17270658}. |
| Top Pathways | cGMP-PKG signaling pathway, Huntington's disease, Glucagon signaling pathway, Prostate cancer, PI3K-Akt signaling pathway |