CYP1A2

Gene Symbol	CYP1A2
Entrez Gene	1544
Alt Symbol	CP12, P3-450, P450(PA)
Species	Human
Gene Type	protein-coding
Description	cytochrome P450, family 1, subfamily A, polypeptide 2
Other Description	CYPIA2|P450 form 4|aryl hydrocarbon hydroxylase|cytochrome P(3)450|cytochrome P450 1A2|cytochrome P450 4|cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2|cytochrome P450-P3|dioxin-inducible P3-450|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
Swissprots	Q16754 Q9UK49 Q6NWU5 Q9BXX7 P05177
Accessions	AAA35738 AAA52163 AAK25728 AAY26399 EAW99313 P05177 AF182274 AAF13599 BC067424 AAH67424 BC067425 AAH67425 BC067426 AAH67426 BC067427 AAH67427 BC067428 AAH67428 BC067429 AAH67429 M12078 AAA52154 M55053 AAA52146 Z00036 CAA77335 NM_000761 NP_000752
Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O- deethylation of phenacetin. {ECO:0000269|PubMed:14725854}.
Subcellular Location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue Specificity	Liver.
Top Pathways	Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450, Tryptophan metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CYP1A2 ELISA Kit (Sandwich ELISA) - LS-F7889 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.238 ng/ml Range 0.625-40 ng/ml

Rat CYP1A2 ELISA Kit (Sandwich ELISA) - LS-F11188 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.625-40 ng/ml

Human Cytochrome P450 1A2 ELISA Kit - abx151240 from Abbexa Category ELISA Kit Sensitivity 0.051 ng/ml Range 0.156 ng/ml - 10 ng/ml

Cytochrome P450, family 1, subfamily A, polypeptide 2, CYP1A2, Human, ELISA Kit - E-EL-H0365 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Cytochrome P450 1A2 (CYP1A2), Human, ELISA Kit - CSB-EL006396HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Cytochrome P450 1A2 (CYP1A2), Human, ELISA Kit - SED294Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.051ng/mL Range 0.156-10ng/mL

Cytochrome P450 1A2 (CYP1A2), Human, ELISA Kit - E01C2226 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 2.5-50ng/ml

Cytochrome P450 1A2, CYP1A2, Human, ELISA Kit - E10137h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Cytochrome P450 1A2, CYP1A2, Rabbit, ELISA Kit - E-EL-RB2130 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Cytochrome P450 1A2, CYP1A2, Chicken, ELISA Kit - E-EL-Ch2044 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Cytochrome P450 1A2, CYP1A2, Porcine, ELISA Kit - E-EL-P0409 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cytochrome P450 1A2, CYP1A2, Sheep, ELISA Kit - E-EL-S0354 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Cytochrome P450 1A2, CYP1A2, Guinea Pig, ELISA Kit - E-EL-GP0462 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Cytochrome P450 1A2, CYP1A2, Monkey, ELISA Kit - E-EL-MK0217 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human CYP1A2(Cytochrome P450, family 1, subfamily A, polypeptide 2) ELISA Kit - E-EL-H0365 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human CYP1A2 (Cytochrome P450, family 1, subfamily A, polypeptide 2) CLIA Kit - E-CL-H0297 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

CYP1A2, ELISA Kit - MBS2503944 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Human CYP1A2 is 0.094ng/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 0.156-10ng/mL

CYP1A2, ELISA Kit - MBS2515761 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

CYP1A2, ELISA Kit - MBS2501939 from MyBioSource Category ELISA Kit Prices $490.00, $585.00, $2,475.00, $4,360.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.469ng/mL Range 0.781-50ng/mL

CYP1A2, ELISA Kit - MBS2512949 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

CYP1A2, ELISA Kit - MBS2511229 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

CYP1A2, ELISA Kit - MBS2508189 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

CYP1A2, ELISA Kit - MBS2504102 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

CYP1A2, ELISA Kit - MBS2509792 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

CYP1A2, ELISA Kit - MBS2516212 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Rat CYP1A2 is 0.094ng/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 0.156-10ng/mL

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