CYP1A2
| Gene Symbol | CYP1A2 |
|---|---|
| Entrez Gene | 1544 |
| Alt Symbol | CP12, P3-450, P450(PA) |
| Species | Human |
| Gene Type | protein-coding |
| Description | cytochrome P450, family 1, subfamily A, polypeptide 2 |
| Other Description | CYPIA2|P450 form 4|aryl hydrocarbon hydroxylase|cytochrome P(3)450|cytochrome P450 1A2|cytochrome P450 4|cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2|cytochrome P450-P3|dioxin-inducible P3-450|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase |
| Swissprots | Q16754 Q9UK49 Q6NWU5 Q9BXX7 P05177 |
| Accessions | AAA35738 AAA52163 AAK25728 AAY26399 EAW99313 P05177 AF182274 AAF13599 BC067424 AAH67424 BC067425 AAH67425 BC067426 AAH67426 BC067427 AAH67427 BC067428 AAH67428 BC067429 AAH67429 M12078 AAA52154 M55053 AAA52146 Z00036 CAA77335 NM_000761 NP_000752 |
| Function | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O- deethylation of phenacetin. {ECO:0000269|PubMed:14725854}. |
| Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
| Tissue Specificity | Liver. |
| Top Pathways | Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450, Tryptophan metabolism |
CYP1A2 CRISPR/Cas9 KO Plasmid (h) - sc-401178 from Santa Cruz Biotechnology
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CYP1A2 HDR Plasmid (h) - sc-401178-HDR from Santa Cruz Biotechnology
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CYP1A2 Double Nickase Plasmid (h) - sc-401178-NIC from Santa Cruz Biotechnology
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CYP1A2 Double Nickase Plasmid (h2) - sc-401178-NIC-2 from Santa Cruz Biotechnology
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CYP1A2 CRISPR Activation Plasmid (h) - sc-401178-ACT from Santa Cruz Biotechnology
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CYP1A2 CRISPR Activation Plasmid (h2) - sc-401178-ACT-2 from Santa Cruz Biotechnology
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CYP1A2 Lentiviral Activation Particles (h) - sc-401178-LAC from Santa Cruz Biotechnology
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CYP1A2 Lentiviral Activation Particles (h2) - sc-401178-LAC-2 from Santa Cruz Biotechnology
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CYP1A2 siRNA (h) - sc-41485 from Santa Cruz Biotechnology
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CYP1A2 shRNA Plasmid (h) - sc-41485-SH from Santa Cruz Biotechnology
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CYP1A2 shRNA (h) Lentiviral Particles - sc-41485-V from Santa Cruz Biotechnology
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Cytochrome P450 1A2 RNAi - H00001544-R01 from Novus Biologicals
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MISSION® esiRNA - EHU030071 from Sigma-Aldrich
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MISSION® esiRNA - EHU019351 from Sigma-Aldrich
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MISSION® esiRNA - EHU001461 from Sigma-Aldrich
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CYP1A2 siRNA (Human) - CRH1091 from Cohesion Biosciences
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CYP1A2 - MBS8205216 from MyBioSource
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CYP1A2 CRISPR/Cas9 KO Plasmid (h2) - sc-401178-KO-2 from Santa Cruz Biotechnology
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CYP1A2 HDR Plasmid (h2) - sc-401178-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CYP1A2 (NM_000761.3) - SHH272877 from Creative biogene
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shRNA set against Human CYP1A2(NM_000761.3) - SHG215601 from Creative biogene
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Human CYP1A2 siRNA - orb261593 from Biorbyt
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CYP1A2 shRNA Plasmid (Human) - CHH1091 from Cohesion Biosciences
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CYP1A2 miRNA 3'UTR clone - MiUTR1H-02611 from Creative biogene
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