| Gene Symbol |
Lamtor4
|
| Entrez Gene |
66096
|
| Alt Symbol |
0910001L09Rik, AV006840
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
|
| Other Description |
UPF0539 protein C7orf59 homolog|late endosomal/lysosomal adaptor and MAPK and MTOR activator 4|ragulator complex protein LAMTOR4
|
| Swissprots |
Q8CF77 B7ZN18 Q8CF66 Q8CEW4
|
| Accessions |
Q8CF66 AK002488 BAC24993 AK003086 BAC25020 AK003250 AK010598 BAC25306 AK146994 BC056178 BC144958 AAI44959 NM_001081108 NP_001074577
|
| Function |
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Lysosome {ECO:0000250}.
|