| Gene Symbol | Lamtor4 |
|---|---|
| Entrez Gene | 66096 |
| Alt Symbol | 0910001L09Rik, AV006840 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 |
| Other Description | UPF0539 protein C7orf59 homolog|late endosomal/lysosomal adaptor and MAPK and MTOR activator 4|ragulator complex protein LAMTOR4 |
| Swissprots | Q8CF77 B7ZN18 Q8CF66 Q8CEW4 |
| Accessions | Q8CF66 AK002488 BAC24993 AK003086 BAC25020 AK003250 AK010598 BAC25306 AK146994 BC056178 BC144958 AAI44959 NM_001081108 NP_001074577 |
| Function | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity). {ECO:0000250}. |
| Subcellular Location | Lysosome {ECO:0000250}. |
LAMTOR4 siRNA (m) - sc-108127 from Santa Cruz Biotechnology
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LAMTOR4 shRNA Plasmid (m) - sc-108127-SH from Santa Cruz Biotechnology
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LAMTOR4 shRNA (m) Lentiviral Particles - sc-108127-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN25021 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND25021 from Sigma-Aldrich
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LAMTOR4 siRNA (Mouse) - CRM6423 from Cohesion Biosciences
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shRNA set against Mouse 0910001L09Rik (NM_001081108.2) - SHH224510 from Creative biogene
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Mouse LAMTOR4 siRNA - orb285899 from Biorbyt
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LAMTOR4 shRNA Plasmid (Mouse) - CHM6423 from Cohesion Biosciences
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