CX3CL1

Gene Symbol CX3CL1
Entrez Gene 6376
Alt Symbol ABCD-3, C3Xkine, CXC3, CXC3C, NTN, NTT, SCYD1, fractalkine, neurotactin
Species Human
Gene Type protein-coding
Description chemokine (C-X3-C motif) ligand 1
Other Description C-X3-C motif chemokine 1|CX3C membrane-anchored chemokine|fractalkine|small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin)|small inducible cytokine subfamily D (Cys-X3-Cys), member-1|small-inducible cytokine D1
Swissprots P78423 O00672
Accessions AAC24307 ABK41928 EAW82919 P78423 AB209037 BAD92274 AK222692 BAD96412 AK223351 BAD97071 AK313806 BAG36542 BC001163 AAH01163 BC016164 AAH16164 CA396869 CR457426 CAG33707 DQ890704 ABM81630 DQ891871 ABM82797 DQ893888 ABM84814 DQ895059 ABM85985 GU047346 HY114023 U84487 AAB49679 U91835 AAB50014 NM_001304392 NP_001291321 NM_002996 NP_002987
Function The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. {ECO:0000269|PubMed:21829356}.
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas.
Top Pathways Cytokine-cytokine receptor interaction, Chemokine signaling pathway, TNF signaling pathway

Active CX3CL1 full length protein - ab9820 from Abcam

Category Protein
Prices $110.00, $257.00
Sizes 5 µg, 20 µg
Source E. coli

Active human CX3CL1 protein fragment - ab108577 from Abcam

Category Protein
Prices $302.00
Sizes 10 µg
Source HEK 293 cells
Species Human
Chemotaxis effect of human CX3CL1-DDDDK (ab108577) in THP-1 Cells. Cell migration of THP-1 monocytic leukemia cells was evaluated in disposable 24 well transwell polystyrene membrane with 8µm size pores. 100ng, 500ng, 1,000ng, 2,500ng and 5,000ng of recombinant CX3CL1 were diluted in RPMI 1640 supplemented with 10mg/ml BSA, respectively. CX3CL1 samples were added to the lower chamber. THP-1 cells (0.5 X 10 6 cells per well), in the same media with ab108577, were added to the upper chamber. After 2 hour incubation at 37°C in 5% CO2 humidified atmosphere, migration cells in the lower chamber were counted. Migrated cells in two separate fields per well from duplicate wells were enumerated on a hemacytometer by means light microscopy.

Active human CX3CL1 protein fragment - ab54434 from Abcam

Category Protein
Prices $315.00
Sizes 20 µg
Source E. coli
Species Human

Active human CX3CL1 protein fragment - ab73766 from Abcam

Category Protein
Prices $200.00
Sizes 20 µg
Source E. coli
Species Human

Active rat CX3CL1 protein fragment - ab201406 from Abcam

Category Protein
Prices $107.00
Sizes 5 µg
Source E. coli
Species Rat

Human CX3CL1 peptide - ab95420 from Abcam

Category Peptide

Human CX3CL1 protein fragment - ab166884 from Abcam

Category Protein
Source E. coli
Species Human
ab166884 is >95% pure by SDS-PAGE.

Human CX3CL1 protein fragment - ab151824 from Abcam

Category Protein
Source HEK 293 cells
Species Human

Human CX3CL1 protein fragment - ab87480 from Abcam

Category Protein
Source E. coli
Species Human
SDS-PAGE showing ab87480.

Human CX3CL1 protein fragment - ab175165 from Abcam

Category Protein
Source Synthetic
Species Human

Human CX3CL1 protein fragment - ab176091 from Abcam

Category Protein
Source Synthetic
Species Human

Mouse CX3CL1 protein fragment - ab175170 from Abcam

Category Protein
Source Synthetic
Species Mouse

Mouse CX3CL1 protein fragment - ab176092 from Abcam

Category Protein
Source Synthetic
Species Mouse

CX3CL1 / Fractalkine Antibody Blocking Peptide - LS-E29887 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

Recombinant Human CX3CL1/Fractalkine Protein - NBP2-34874 from Novus Biologicals

Category Protein
Prices $69.00, $169.00, $2,669.00
Sizes 5 µg, 20 µg, 1 mg
Source E. coli
Species Human
SDS-Page: Human CX3CL1/Fractalkine Protein [NBP2-34874]

CX3CL1/Fractalkine Partial Recombinant Protein - H00006376-Q01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

CX3CL1/Fractalkine Recombinant Protein - H00006376-P01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

Recombinant Human CX3CL1/Fractalkine Protein - NBP1-30220 from Novus Biologicals

Category Protein
Prices $499.00
Sizes 100 µg
Species Human
SDS-Page: CX3CL1 Protein [NBP1-30220] - CX3CL1/Fractalkine, 10.9 kDa (97aa), confirmed by MALDI-TOF with a purity of 90% by SDS - PAGE

CX3CL1/Fractalkine Recombinant Protein - P3973 from Novus Biologicals

Category Protein
Prices $549.00
Sizes 20 µg
Species Human

CX3CL1/Fractalkine Blocking Peptide - NBP1-76467PEP from Novus Biologicals

Category Peptide
Prices $129.00
Sizes 50 µg
Species Human

CX3CL1/Fractalkine Protein - NBP1-99250 from Novus Biologicals

Category Protein
Species Human

Recombinant Human CX3CL1/Fractalkine Protein - NBP1-99653 from Novus Biologicals

Category Protein
Prices $495.00
Sizes 100 µg
Source E. coli
Species Human

Fractalkine recombinant protein - GTX65254 from GeneTex

Category Protein
Prices $249.00
Sizes 20 μg
Source E. coli
Species Human

Fractalkine Recombinant Protein (Active) - GTX48357-PRO from GeneTex

Category Protein
Prices $299.00
Sizes 20 μg
Source E. coli
Species Human

Recombinant Human CX3CL1/Fractalkine (Full Length) - 365-FR-025 from R&D Systems

Category Protein
Source Mouse myeloma cell line, NS0-derived
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