Gene Symbol | CX3CL1 |
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Entrez Gene | 6376 |
Alt Symbol | ABCD-3, C3Xkine, CXC3, CXC3C, NTN, NTT, SCYD1, fractalkine, neurotactin |
Species | Human |
Gene Type | protein-coding |
Description | chemokine (C-X3-C motif) ligand 1 |
Other Description | C-X3-C motif chemokine 1|CX3C membrane-anchored chemokine|fractalkine|small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin)|small inducible cytokine subfamily D (Cys-X3-Cys), member-1|small-inducible cytokine D1 |
Swissprots | P78423 O00672 |
Accessions | AAC24307 ABK41928 EAW82919 P78423 AB209037 BAD92274 AK222692 BAD96412 AK223351 BAD97071 AK313806 BAG36542 BC001163 AAH01163 BC016164 AAH16164 CA396869 CR457426 CAG33707 DQ890704 ABM81630 DQ891871 ABM82797 DQ893888 ABM84814 DQ895059 ABM85985 GU047346 HY114023 U84487 AAB49679 U91835 AAB50014 NM_001304392 NP_001291321 NM_002996 NP_002987 |
Function | The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. {ECO:0000269|PubMed:21829356}. |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
Tissue Specificity | Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas. |
Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway, TNF signaling pathway |
Active CX3CL1 full length protein - ab9820 from Abcam
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Active human CX3CL1 protein fragment - ab108577 from Abcam
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Active human CX3CL1 protein fragment - ab54434 from Abcam
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Active human CX3CL1 protein fragment - ab73766 from Abcam
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Active rat CX3CL1 protein fragment - ab201406 from Abcam
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Human CX3CL1 peptide - ab95420 from Abcam
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Human CX3CL1 protein fragment - ab166884 from Abcam
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Human CX3CL1 protein fragment - ab151824 from Abcam
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Human CX3CL1 protein fragment - ab87480 from Abcam
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Human CX3CL1 protein fragment - ab175165 from Abcam
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Human CX3CL1 protein fragment - ab176091 from Abcam
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Mouse CX3CL1 protein fragment - ab175170 from Abcam
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Mouse CX3CL1 protein fragment - ab176092 from Abcam
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CX3CL1 / Fractalkine Antibody Blocking Peptide - LS-E29887 from LifeSpan Bioscience
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Recombinant Human CX3CL1/Fractalkine Protein - NBP2-34874 from Novus Biologicals
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CX3CL1/Fractalkine Partial Recombinant Protein - H00006376-Q01 from Novus Biologicals
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CX3CL1/Fractalkine Recombinant Protein - H00006376-P01 from Novus Biologicals
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Recombinant Human CX3CL1/Fractalkine Protein - NBP1-30220 from Novus Biologicals
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CX3CL1/Fractalkine Recombinant Protein - P3973 from Novus Biologicals
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CX3CL1/Fractalkine Blocking Peptide - NBP1-76467PEP from Novus Biologicals
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CX3CL1/Fractalkine Protein - NBP1-99250 from Novus Biologicals
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Recombinant Human CX3CL1/Fractalkine Protein - NBP1-99653 from Novus Biologicals
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Fractalkine recombinant protein - GTX65254 from GeneTex
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Fractalkine Recombinant Protein (Active) - GTX48357-PRO from GeneTex
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Recombinant Human CX3CL1/Fractalkine (Full Length) - 365-FR-025 from R&D Systems
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