| Gene Symbol |
Smad4
|
| Entrez Gene |
17128
|
| Alt Symbol |
AW743858, D18Wsu70e, DPC4, Madh4
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
SMAD family member 4
|
| Other Description |
MAD homolog 4|Smad 4|deletion target in pancreatic carcinoma 4 homolog|mothers against DPP homolog 4|mothers against decapentaplegic homolog 4
|
| Swissprots |
Q9CW56 Q6GTP6 P97471
|
| Accessions |
AAM74472 EDL09559 EDL09560 EDL09561 P97471 AB221585 AK004804 BAB23576 AK170255 AY493561 AAR85497 BC046584 AAH46584 GU072917 ADO32891 GU072918 ADO32892 GU072919 ADO32893 GU072920 ADO32894 U79748 AAB57905 XM_006525701 XP_006525764 XM_006525702 XP_006525765 XM_011246855 XP_011245157 NM_008540 NP_032566
|
| Function |
Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14- 3-3 protein YWHAQ which acts as a negative regulator (By similarity). Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac a
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with R-SMAD. PDPK1 prevents its nuclear translocation (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Wnt signaling pathway, Pancreatic cancer, HTLV-I infection, Colorectal cancer, Chronic myeloid leukemia
|