Smad4

Gene Symbol Smad4
Entrez Gene 17128
Alt Symbol AW743858, D18Wsu70e, DPC4, Madh4
Species Mouse
Gene Type protein-coding
Description SMAD family member 4
Other Description MAD homolog 4|Smad 4|deletion target in pancreatic carcinoma 4 homolog|mothers against DPP homolog 4|mothers against decapentaplegic homolog 4
Swissprots Q9CW56 Q6GTP6 P97471
Accessions AAM74472 EDL09559 EDL09560 EDL09561 P97471 AB221585 AK004804 BAB23576 AK170255 AY493561 AAR85497 BC046584 AAH46584 GU072917 ADO32891 GU072918 ADO32892 GU072919 ADO32893 GU072920 ADO32894 U79748 AAB57905 XM_006525701 XP_006525764 XM_006525702 XP_006525765 XM_011246855 XP_011245157 NM_008540 NP_032566
Function Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14- 3-3 protein YWHAQ which acts as a negative regulator (By similarity). Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac a
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with R-SMAD. PDPK1 prevents its nuclear translocation (By similarity). {ECO:0000250}.
Tissue Specificity Ubiquitous.
Top Pathways Wnt signaling pathway, Pancreatic cancer, HTLV-I infection, Colorectal cancer, Chronic myeloid leukemia

Biotinylated-SMAD4-T277-Non-phospho-Control-Peptide - SP2077d from Abgent, a WuXi AppTec company

Category Peptide
Prices $150.00
Sizes 1 mg

SMAD4-T277-Non-phospho-Control-Peptide - SP2077c from Abgent, a WuXi AppTec company

Category Peptide
Prices $132.00
Sizes 1 mg

Biotinylated-SMAD4-T277-Phospho-Peptide - SP2077b from Abgent, a WuXi AppTec company

Category Peptide
Prices $300.00
Sizes 1 mg

SMAD4-T277-Phospho-Peptide - SP2077a from Abgent, a WuXi AppTec company

Category Peptide
Prices $150.00
Sizes 1 mg

Mouse Smad4 Protein - abx068074 from Abbexa

Category Protein
Source E.coli
Species Mouse

Recombinant Mothers Against Decapentaplegic Homolog 4 (Smad4) - RPB925Mu01 from Cloud-clone

Category Protein
Source E.coli
Species Mouse

Recombinant Mouse Mothers against decapentaplegic homolog 4(Smad4) - CSB-YP021789MO CSB-EP021789MO CSB-BP021789MO CSB-MP021789MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Mothers Against Decapentaplegic Homolog 4 (Smad4) - RPU142809 from Biomatik

Category Protein
Prices $240.90, $481.80, $722.70
Sizes 10 µg, 50 µg, 100 µg
Source E.coli
Species Mouse

Recombinant Mouse SMAD4 Protein - SMAD4-15587M from Creative Biomart

Category Protein
Source Mammalian Cells
Species Mouse

Recombinant Mothers Against Decapentaplegic Homolog 4 (Smad4) - RPU42809 from Biomatik

Category Protein
Prices $193.00, $394.00, $603.00, $718.32
Sizes 10 µg, 50 µg, 100 µg, 200 µg
Source E.coli
Species Mouse

SMAD4 Recombinant Protein (OPCD07066) - OPCD07066 from Aviva Systems Biology

Category Protein
Source E.coli
Species Mouse

Mothers against decapentaplegic homolog 4 (Smad4), Recombinant Protein - MBS949238 from MyBioSource

Category Protein
Prices $1,345.00, $1,345.00, $1,565.00, $1,565.00, $2,230.00, $2,230.00, $2,695.00, $2,695.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse
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