Smad4

Gene Symbol	Smad4
Entrez Gene	17128
Alt Symbol	AW743858, D18Wsu70e, DPC4, Madh4
Species	Mouse
Gene Type	protein-coding
Description	SMAD family member 4
Other Description	MAD homolog 4|Smad 4|deletion target in pancreatic carcinoma 4 homolog|mothers against DPP homolog 4|mothers against decapentaplegic homolog 4
Swissprots	Q9CW56 Q6GTP6 P97471
Accessions	AAM74472 EDL09559 EDL09560 EDL09561 P97471 AB221585 AK004804 BAB23576 AK170255 AY493561 AAR85497 BC046584 AAH46584 GU072917 ADO32891 GU072918 ADO32892 GU072919 ADO32893 GU072920 ADO32894 U79748 AAB57905 XM_006525701 XP_006525764 XM_006525702 XP_006525765 XM_011246855 XP_011245157 NM_008540 NP_032566
Function	Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14- 3-3 protein YWHAQ which acts as a negative regulator (By similarity). Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac a
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with R-SMAD. PDPK1 prevents its nuclear translocation (By similarity). {ECO:0000250}.
Tissue Specificity	Ubiquitous.
Top Pathways	Wnt signaling pathway, Pancreatic cancer, HTLV-I infection, Colorectal cancer, Chronic myeloid leukemia

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

SignalSilence ® Smad4 siRNA I (Mouse Specific) - 12791 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

Smad4 CRISPR/Cas9 KO Plasmid (m) - sc-421527 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

Smad4 HDR Plasmid (m) - sc-421527-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

Smad4 Double Nickase Plasmid (m) - sc-421527-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

Smad4 Double Nickase Plasmid (m2) - sc-421527-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

Smad4 CRISPR Activation Plasmid (m) - sc-421527-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

Smad4 CRISPR Activation Plasmid (m2) - sc-421527-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

Smad4 Lentiviral Activation Particles (m) - sc-421527-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

Smad4 Lentiviral Activation Particles (m2) - sc-421527-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

Smad4 siRNA (m) - sc-29485 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

Smad4 shRNA Plasmid (m) - sc-29485-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

Smad4 shRNA (m) Lentiviral Particles - sc-29485-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

Smad4 siRNA (m2) - sc-44274 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

Smad4 shRNA Plasmid (m2) - sc-44274-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

Smad4 shRNA (m2) Lentiviral Particles - sc-44274-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

MISSION® esiRNA - EMU016021 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN41642 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND41642 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

SMAD4 siRNA (Mouse) - CRM2436 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

SMAD4 - MBS8207765 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

shRNA set against Mouse SMAD4 (NM_008540.2) - SHH412988 from Creative biogene Category siRNA Species Reactivities Mouse

shRNA set against Mouse Smad4(NM_008540.2) - SHL015156 from Creative biogene Category siRNA Species Reactivities Mouse

Mouse SMAD4 siRNA - orb281912 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

SMAD4 shRNA Plasmid (Mouse) - CHM2436 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Mouse

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