| Gene Symbol |
KDM1B
|
| Entrez Gene |
221656
|
| Alt Symbol |
AOF1, C6orf193, LSD2, bA204B7.3, dJ298J15.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysine (K)-specific demethylase 1B
|
| Other Description |
amine oxidase (flavin containing) domain 1|amine oxidase, flavin containing 1|flavin-containing amine oxidase domain-containing protein 1|lysine-specific histone demethylase 1B|lysine-specific histone demethylase 2
|
| Swissprots |
Q8N258 Q6ZUU4 Q6AI15 Q5TGV3 Q96EL7 A2A2C6 A2A2C5 Q8NB78
|
| Accessions |
EAW55400 EAW55401 Q8NB78 AA332652 AJ420481 AK091217 BAC03612 AK125318 BAC86124 BC113093 AAI13094 CR627410 CAH10499 DA099422 XM_005248925 XP_005248982 XM_005248926 XP_005248983 XM_005248927 XP_005248984 XM_005248928 XP_005248985 XM_005248929 XP_005248986 XM_011514385 XP_011512687 XM_011514386 XP_011512688 NM_153042 NP_694587
|
| Function |
Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri- methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys- 36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
![Western Blot: AOF1 Overexpression Lysate (Adult Normal) [NBP2-04430] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AOF1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3968_AOF1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04430-img0001.jpg)