KDM1B

Gene Symbol KDM1B
Entrez Gene 221656
Alt Symbol AOF1, C6orf193, LSD2, bA204B7.3, dJ298J15.2
Species Human
Gene Type protein-coding
Description lysine (K)-specific demethylase 1B
Other Description amine oxidase (flavin containing) domain 1|amine oxidase, flavin containing 1|flavin-containing amine oxidase domain-containing protein 1|lysine-specific histone demethylase 1B|lysine-specific histone demethylase 2
Swissprots Q8N258 Q6ZUU4 Q6AI15 Q5TGV3 Q96EL7 A2A2C6 A2A2C5 Q8NB78
Accessions EAW55400 EAW55401 Q8NB78 AA332652 AJ420481 AK091217 BAC03612 AK125318 BAC86124 BC113093 AAI13094 CR627410 CAH10499 DA099422 XM_005248925 XP_005248982 XM_005248926 XP_005248983 XM_005248927 XP_005248984 XM_005248928 XP_005248985 XM_005248929 XP_005248986 XM_011514385 XP_011512687 XM_011514386 XP_011512688 NM_153042 NP_694587
Function Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri- methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys- 36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000250}.

AOF1 (K-17) - sc-103387 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AOF1 (K-17): sc-103387. Western blot analysis of AOF1 expression in HeLa (A), NIH/3T3 (B), Jurkat (C) and K-562 (D) nuclear extracts.

AOF1 (V-20) - sc-103388 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-LSD2 / AOF1 antibody - ab34464 from Abcam

Prices $368.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LSD2 / AOF1 antibody - ChIP Grade - ab134997 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Total extracts from mouse thymus were immunoprecipitated (IP) with IgG(Lanes 1 and 3) or ab134997 (Lanes 3 and 4) using conventional IP conditions or cross-linked chromatin immunoprecipitation (ChIP) conditions; followed by WB with ab134997 at RT for 2 h.

Anti-LSD2 / AOF1 antibody - N-terminal - ab178599 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-LSD2 / AOF1 antibody - N-terminal (ab178599) at 1 µg/ml + A549 whole cell lysate at 10 µg

Anti-KDM1B Antibody (aa67-116) - LS-C186799 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human A549. KDM1B antibody dilution 1.0 ug/ml.

Anti-KDM1B Antibody (aa490-520, Azide-free, HRP) - LS-C249433 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM1B Antibody (aa490-520) - LS-C319505 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM1B Antibody (N-Terminus) - LS-C347719 from LifeSpan Bioscience

Prices $345.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM1B Antibody (N-Terminus) IHC-plus™ - LS-B10141 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KDM1B antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10141 concentration 10 ug/ml.

Anti-KDM1B Antibody (aa490-520, APC) - LS-C232706 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM1B Antibody (aa490-520, AP) - LS-C232707 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM1B Antibody (aa490-520, Biotin) - LS-C232708 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM1B Antibody (aa490-520, FITC) - LS-C232709 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM1B Antibody (aa490-520, PE) - LS-C232711 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

AOF1 Antibody - NBP1-90148 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: AOF1 Antibody [NBP1-90148] - Immunofluorescent staining of human cell line A-431 shows localization to nucleus.

Anti-KDM1B antibody produced in rabbit - HPA031269 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-KDM1B: <B>Cat. No. HPA031269</B>: Immunohistochemical staining of human liver shows nuclear and cytoplasmic positivity in hepatocytes.

Anti-KDM1B antibody produced in rabbit - SAB3501055 from Sigma-Aldrich

Prices $341.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>KDM1B Antibody: <B>Cat. No. SAB3501055</B>: Western blot analysis of KDM1B in 3T3 cell lysate with KDM1B antibody at 2 μg/mL in (Lane A) the absence and (Lane B) the presence of blocking peptide.

KDM1B Antibody - N-terminal region (ARP66383_P050) - ARP66383_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KDM1B-Antibody-N-term - AP21020a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysates from Raji, K562 cell line (from left to right), using KDM1B Antibody (N-term)(Cat. #AP21020a). AP21020a was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.
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