| Gene Symbol | KDM1B |
|---|---|
| Entrez Gene | 221656 |
| Alt Symbol | AOF1, C6orf193, LSD2, bA204B7.3, dJ298J15.2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | lysine (K)-specific demethylase 1B |
| Other Description | amine oxidase (flavin containing) domain 1|amine oxidase, flavin containing 1|flavin-containing amine oxidase domain-containing protein 1|lysine-specific histone demethylase 1B|lysine-specific histone demethylase 2 |
| Swissprots | Q8N258 Q6ZUU4 Q6AI15 Q5TGV3 Q96EL7 A2A2C6 A2A2C5 Q8NB78 |
| Accessions | EAW55400 EAW55401 Q8NB78 AA332652 AJ420481 AK091217 BAC03612 AK125318 BAC86124 BC113093 AAI13094 CR627410 CAH10499 DA099422 XM_005248925 XP_005248982 XM_005248926 XP_005248983 XM_005248927 XP_005248984 XM_005248928 XP_005248985 XM_005248929 XP_005248986 XM_011514385 XP_011512687 XM_011514386 XP_011512688 NM_153042 NP_694587 |
| Function | Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri- methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys- 36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000250}. |
AOF1 CRISPR/Cas9 KO Plasmid (h) - sc-405078 from Santa Cruz Biotechnology
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AOF1 HDR Plasmid (h) - sc-405078-HDR from Santa Cruz Biotechnology
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AOF1 Double Nickase Plasmid (h) - sc-405078-NIC from Santa Cruz Biotechnology
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AOF1 Double Nickase Plasmid (h2) - sc-405078-NIC-2 from Santa Cruz Biotechnology
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AOF1 CRISPR Activation Plasmid (h) - sc-405078-ACT from Santa Cruz Biotechnology
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AOF1 CRISPR Activation Plasmid (h2) - sc-405078-ACT-2 from Santa Cruz Biotechnology
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AOF1 Lentiviral Activation Particles (h) - sc-405078-LAC from Santa Cruz Biotechnology
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AOF1 Lentiviral Activation Particles (h2) - sc-405078-LAC-2 from Santa Cruz Biotechnology
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AOF1 siRNA (h) - sc-95467 from Santa Cruz Biotechnology
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AOF1 shRNA Plasmid (h) - sc-95467-SH from Santa Cruz Biotechnology
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AOF1 shRNA (h) Lentiviral Particles - sc-95467-V from Santa Cruz Biotechnology
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AOF1 RNAi - H00221656-R01 from Novus Biologicals
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MISSION® esiRNA - EHU052581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11025 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11025 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10694 from Sigma-Aldrich
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KDM1B siRNA (Human) - CRJ6529 from Cohesion Biosciences
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shRNA set against Human KDM1B (NM_153042.3) - SHH324139 from Creative biogene
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shRNA set against Human AOF1(NM_153042.3) - SHG062487 from Creative biogene
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Human KDM1B siRNA - orb277030 from Biorbyt
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KDM1B shRNA Plasmid (Human) - CHJ6529 from Cohesion Biosciences
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KDM1B miRNA 3'UTR clone - MiUTR1H-00432 from Creative biogene
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