| Gene Symbol |
TUBB4A
|
| Entrez Gene |
10382
|
| Alt Symbol |
DYT4, TUBB4, beta-5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tubulin, beta 4A class IVa
|
| Other Description |
dystonia 4, torsion (autosomal dominant)|tubulin beta-4 chain|tubulin beta-4A chain|tubulin, beta 4|tubulin, beta, 5
|
| Swissprots |
Q969E5 P04350 B3KQP4
|
| Accessions |
CAA25318 CAF86918 EAW69078 EAW69079 P04350 AK075307 BAG52106 AK095202 AK293503 BAG56988 AK294102 BAG57437 AK295917 BAG58705 BC006570 AAH06570 BC013683 AAH13683 DA265791 DA302559 DC303150 DC314277 DC353527 DC354036 EU831818 ACE87336 EU831895 ACE86654 NM_001289123 NP_001276052 NM_001289127 NP_001276056 NM_001289129 NP_001276058 NM_001289130 NP_001276059 NM_001289131 NP_001276060 NM_006087 NP_006078
|
| Function |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
|
| Subcellular Location |
Cytoplasm, cytoskeleton.
|
| Tissue Specificity |
Major isotype in brain, where it represents 46% of all beta-tubulins. In the brain, highest expression levels in the cerebellum, followed by putamen and white matter. Moderate levels in testis. Very low levels, if any, in other tissues. {ECO:0000269|PubMed:20191564, ECO:0000269|PubMed:23424103}.
|
| Top Pathways |
Gap junction, Pathogenic Escherichia coli infection, Phagosome
|