PENK

Gene Symbol PENK
Entrez Gene 5179
Alt Symbol -
Species Human
Gene Type protein-coding
Description proenkephalin
Other Description enkephalin A|preproenkephalin|proenkephalin-A
Swissprots B2RC23 Q6FHE6 Q6FHC6 P01210
Accessions AAB59409 CAA23767 EAW86785 EAW86786 EAW86787 P01210 AK309758 AK314908 BAG37420 BC032505 AAH32505 BC107706 AAI07707 BI496610 BI913625 CR541808 CAG46607 CR541828 CAG46627 DB496514 DQ890865 ABM81791 DQ890871 ABM81797 DQ894027 ABM84953 NM_001135690 NP_001129162 NM_006211 NP_006202
Function Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.
Subcellular Location Secreted.

Met-enkephalin (1194/334) - sc-80877 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Met/Leu-enkephalin (NOC1/35) - sc-47705 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Met/Leu-enkephalin (NOC1/35): sc-47705. Immunoperoxidase staining of formalin-fixed, paraffin-embedded rat brain tissue showing Enkephalin positivecells inthe Ventral Lateral Striatum.Image kindly provided by Regina Vontell, Adrienne Betz and John Salamone, University of Connecticut

Synenkephalin (N-13) - sc-46545 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Synenkephalin (N-13): sc-46545. Western blot analysis of Synenkephalin expression in mouse testis tissue extract.

Anti-Enkephalin antibody - ab77273 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-Enkephalin antibody (ab77273) at 0.3 µg/ml + Human Adrenal Gland lysate in RIPA buffer at 35 µg

Anti-Enkephalin antibody - ab98128 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Enkephalin antibody (ab98128) at 1 µg/ml (in 5% skim milk / PBS buffer) + Jurkat cell lysate at 10 µg

Anti-Enkephalin antibody [NOC1] - ab150346 from Abcam

Prices $370.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone NOC1

Anti-Leu + Met Enkephalin antibody - ab172085 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-Leu + Met Enkephalin antibody (ab172085) at 1/500 dilutionLane 1 : Leu + Met Enkephalin-transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H+L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-Leu + Met Enkephalin antibody [M09201] - ab6542 from Abcam

Prices $370.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone M09201

Anti-Leu Enkephalin antibody - ab22619 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ab22619 (4µg/ml) staining leu enkephalin in human testis using an automated system (DAKO Autostainer Plus). Using this protocol there is cytoplasmic staining of seminal vesicles.Sections were rehydrated and antigen retrieved with the Dako 3 in 1 AR buffer citrate pH 6.0 in a DAKO PT link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 mins. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 min and detected with Dako Envision Flex amplification kit for 30 minutes. Colorimetric detection was completed with Diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that, for manual staining, optimization of primary antibody concentration and incubation time is recommended. Signal amplification may be required.

Anti-Leu Enkephalin antibody - ab85798 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Leu Enkephalin antibody (ab85798) at 1 µg/ml + Testis (Human) Tissue Lysate - adult normal tissue (ab30257) at 10 µgSecondaryGoat polyclonal Secondary Antibody to Rabbit IgG - H&L (HRP), pre-adsorbed at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Met Enkephalin antibody - ab22620 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab22620 stained SHSY5Y cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab22620, 1/1000 dilution) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Proenkephalin / PENK Antibody (aa143-192) IHC-plus™ - LS-B11628 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-Proenkephalin / PENK Antibody (C-Terminus) - LS-C23074 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-Proenkephalin / PENK Antibody (C-Terminus) - LS-C23078 from LifeSpan Bioscience

Prices $515.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal

Anti-Proenkephalin / PENK Antibody - LS-C23079 from LifeSpan Bioscience

Prices $445.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-Proenkephalin / PENK Antibody - LS-C23080 from LifeSpan Bioscience

Prices $495.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-Proenkephalin / PENK Antibody (N-Terminus) - LS-C23082 from LifeSpan Bioscience

Prices $465.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-Proenkephalin / PENK Antibody - LS-C38133 from LifeSpan Bioscience

Prices $560.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Proenkephalin / PENK Antibody - LS-C23084 from LifeSpan Bioscience

Prices $405.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-Proenkephalin / PENK Antibody - LS-C41876 from LifeSpan Bioscience

Prices $330.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-Proenkephalin / PENK Antibody - LS-C42742 from LifeSpan Bioscience

Prices $535.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Proenkephalin / PENK Antibody - LS-C65347 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Proenkephalin / PENK Antibody - LS-C121765 from LifeSpan Bioscience

Prices $605.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-Proenkephalin / PENK Antibody (N-Terminus) - LS-C125495 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Proenkephalin / PENK Antibody (Internal) - LS-C87228 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
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