| Gene Symbol |
PENK
|
| Entrez Gene |
5179
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proenkephalin
|
| Other Description |
enkephalin A|preproenkephalin|proenkephalin-A
|
| Swissprots |
B2RC23 Q6FHE6 Q6FHC6 P01210
|
| Accessions |
AAB59409 CAA23767 EAW86785 EAW86786 EAW86787 P01210 AK309758 AK314908 BAG37420 BC032505 AAH32505 BC107706 AAI07707 BI496610 BI913625 CR541808 CAG46607 CR541828 CAG46627 DB496514 DQ890865 ABM81791 DQ890871 ABM81797 DQ894027 ABM84953 NM_001135690 NP_001129162 NM_006211 NP_006202
|
| Function |
Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.
|
| Subcellular Location |
Secreted.
|