Gene Symbol | PENK |
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Entrez Gene | 5179 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | proenkephalin |
Other Description | enkephalin A|preproenkephalin|proenkephalin-A |
Swissprots | B2RC23 Q6FHE6 Q6FHC6 P01210 |
Accessions | AAB59409 CAA23767 EAW86785 EAW86786 EAW86787 P01210 AK309758 AK314908 BAG37420 BC032505 AAH32505 BC107706 AAI07707 BI496610 BI913625 CR541808 CAG46607 CR541828 CAG46627 DB496514 DQ890865 ABM81791 DQ890871 ABM81797 DQ894027 ABM84953 NM_001135690 NP_001129162 NM_006211 NP_006202 |
Function | Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum. |
Subcellular Location | Secreted. |
Synenkephalin CRISPR/Cas9 KO Plasmid (h) - sc-403894 from Santa Cruz Biotechnology
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Synenkephalin HDR Plasmid (h) - sc-403894-HDR from Santa Cruz Biotechnology
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Synenkephalin Double Nickase Plasmid (h) - sc-403894-NIC from Santa Cruz Biotechnology
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Synenkephalin Double Nickase Plasmid (h2) - sc-403894-NIC-2 from Santa Cruz Biotechnology
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Synenkephalin CRISPR Activation Plasmid (h) - sc-403894-ACT from Santa Cruz Biotechnology
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Synenkephalin CRISPR Activation Plasmid (h2) - sc-403894-ACT-2 from Santa Cruz Biotechnology
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Synenkephalin Lentiviral Activation Particles (h) - sc-403894-LAC from Santa Cruz Biotechnology
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Synenkephalin Lentiviral Activation Particles (h2) - sc-403894-LAC-2 from Santa Cruz Biotechnology
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Proenkephalin A siRNA (h) - sc-45771 from Santa Cruz Biotechnology
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proenkephalin A shRNA Plasmid (h) - sc-45771-SH from Santa Cruz Biotechnology
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proenkephalin A shRNA (h) Lentiviral Particles - sc-45771-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN16620 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16620 from Sigma-Aldrich
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PENK siRNA (Human) - CRH3457 from Cohesion Biosciences
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shRNA set against Human PENK (NM_006211.3) - SHH373504 from Creative biogene
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Human PENK siRNA - orb263959 from Biorbyt
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PENK shRNA Plasmid (Human) - CHH3457 from Cohesion Biosciences
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PENK miRNA 3'UTR clone - MiUTR3H-00736 from Creative biogene
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PENK miRNA 3'UTR clone - MiUTR3H-00737 from Creative biogene
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