| Gene Symbol |
CARD9
|
| Entrez Gene |
64170
|
| Alt Symbol |
CANDF2, hCARD9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
caspase recruitment domain family, member 9
|
| Other Description |
caspase recruitment domain-containing protein 9
|
| Swissprots |
Q5SXM6 Q5SXM5 Q9H854 Q9H257
|
| Accessions |
EAW88219 EAW88220 EAW88221 EAW88222 EAW88223 EAW88224 Q9H257 AF311287 AAG28790 AK024001 BAB14766 AK127481 AK292081 BAF84770 AK295647 BAG58517 AK309043 BC008877 AAH08877 BC035805 BI524042 BM148244 DQ893526 ABM84452 EU176781 ABW03582 NM_052813 NP_434700 NM_052814 NP_434701
|
| Function |
Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM- tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activat
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11053425}.
|
| Tissue Specificity |
Highly expressed in spleen. Also detected in liver, placenta, lung, peripheral blood leukocytes and in brain.
|
| Top Pathways |
NOD-like receptor signaling pathway, Tuberculosis
|