CARD9

Gene Symbol	CARD9
Entrez Gene	64170
Alt Symbol	CANDF2, hCARD9
Species	Human
Gene Type	protein-coding
Description	caspase recruitment domain family, member 9
Other Description	caspase recruitment domain-containing protein 9
Swissprots	Q5SXM6 Q5SXM5 Q9H854 Q9H257
Accessions	EAW88219 EAW88220 EAW88221 EAW88222 EAW88223 EAW88224 Q9H257 AF311287 AAG28790 AK024001 BAB14766 AK127481 AK292081 BAF84770 AK295647 BAG58517 AK309043 BC008877 AAH08877 BC035805 BI524042 BM148244 DQ893526 ABM84452 EU176781 ABW03582 NM_052813 NP_434700 NM_052814 NP_434701
Function	Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM- tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activat
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11053425}.
Tissue Specificity	Highly expressed in spleen. Also detected in liver, placenta, lung, peripheral blood leukocytes and in brain.
Top Pathways	NOD-like receptor signaling pathway, Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CARD9 peptide - ab173036 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human CARD9 full length protein - ab131800 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human CARD9 peptide - ab9650 from Abcam Category Peptide Prices $181.00 Sizes 50 µg Species Human

Human CARD9 protein fragment - ab163797 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

CARD9 Blocking Peptide - LS-E8068 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CARD9 Antibody Blocking Peptide - LS-E21074 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CARD9 Antibody Blocking Peptide - LS-E29985 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human CARD9 Protein - H00064170-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human CARD9 Protein - H00064170-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CARD9 Blocking Peptide - NBP1-76679PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

CARD9-Antibody-N-term-Blocking-peptide - BP5985a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CARD9 peptide - GTX29650 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

CARD9 Blocking Peptide - 33R-1338 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CARD9 - H00064170-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CARD9 - H00064170-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CARD9 - H00064170-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CARD9 - H00064170-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CARD9 Control Peptide - AP30185CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

CARD9 Peptide - 2515P from ProSci Category Peptide Species Human

CARD9 fusion protein - ag1057 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Caspase Recruitment Domain Family, Member 9 (CARD9) - RPP108Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Caspase Recruitment Domain Family, Member 9 (CARD9) - RPP108Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Caspase Recruitment Domain Family, Member 9 (CARD9) - RPP108Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Caspase recruitment domain-containing protein 9(CARD9) - CSB-YP867133HU CSB-EP867133HU CSB-BP867133HU CSB-MP867133HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Caspase Recruitment Domain Family, Member 9 Protein (Recombinant) - abx166700 from Abbexa Category Protein Source Human Species Human

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