| Gene Symbol |
SLC8A3
|
| Entrez Gene |
6547
|
| Alt Symbol |
NCX3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 8 (sodium/calcium exchanger), member 3
|
| Other Description |
Na(+)/Ca(2+)-exchange protein 3|Na+/Ca2+ exchanger 3|sodium/calcium exchanger 3|sodium/calcium exchanger SLC8A3|solute carrier family 8 (sodium-calcium exchanger), member 3|solute carrier family 8 member 3
|
| Swissprots |
Q5K3P6 Q96QG1 Q8IUE9 Q5K3P7 Q8NFI7 Q96QG2 Q8IUF0 P57103
|
| Accessions |
AAM90955 CCQ43930 EAW81018 EAW81019 EAW81020 EAW81021 EAW81022 EAW81023 EAW81024 EAW81025 EAW81026 P57103 AF510501 AAN60790 AF510502 AAN60791 AF510503 AAN60792 AJ304852 CAC40984 AJ304853 CAC40985 AJ508602 CAD48420 AJ745101 CAG33739 AJ745102 CAG33740 AK096553 BAG53321 AK122728 BAG53692 BC023215 BC036783 BC114217 BC142969 AAI42970 BC150183 AAI50184 BC150193 AAI50194 BC160014 AAI60014 BI551720 BI906774 BX098112 BX248763 CAD66570 DA351808 XM_005268017 XP_005268074 XM_005268018 XP_005268075 XM_006720240 XP_006720303 XM_011537101 XP_011535403 XM_011537102 XP_011535404 NM_001130417 NP_001123889 NM_033262 NP_150287 NM_058240 NP_489479 NM_182932 NP_891977 NM_182936 NP_891981 NM_183002 NP_892114 NR_104122 NM_182933
|
| Function |
Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle. {ECO:0000269|PubMed:15777725}.
|
| Top Pathways |
Calcium signaling pathway, Protein digestion and absorption, cGMP-PKG signaling pathway
|